In vitro–In vivo Correlation Studies of Modified Release Solifenacin Tablet Dosage Form

Abstract

A modified release formulation of Solifenacin tablet, was investigated in rabbit for pharmacokinetic and in vitro–in vivo correlation studies. In vivo study was conducted in New Zealand albino male rabbit plasma and In vitro release studies were conducted in simulated gastric fluid and analyzed by using validated HPLC method. The In vivo–In vitro correlation coefficients obtained from point-to-point analysis were greater than 99% between concentrations at certain time points obtained from release study in simulated gastric fluid at specific RPMs and HPLC analysis of rabbit’s plasma. From the in vitro–in vivo correlation prediction it was evident that the Solifenacin modified release tablet is a good for controlled delivery of Solifenacin.