Measurement of Serum Lipid Profile Parameters, Blood Urea Nitrogen, Serum Uric Acid and Serum Creatinine Levels for Children with Acute Lymphoblastic Leukemia

Abstract

Introduction: Leukemia is the commonest malignancy of childhood and is the causative of a third of childhood cancer deaths. Lipid abnormalities have been recognized in children with acute lymphoblastic leukemia (All). Kidney involvement in leukemia can be quite immense. Aim: This study aimed to investigate impact of childhood acute lymphoblastic leukemia and chemotherapy on serum lipid profile parameters and serum renal function tests and on body function. Study Design: This study is carried out on pediatric patients with all. Place and Duration of Study: The study was done on children diagnosed with all attended between October 2015 to December 2016 the Central Child Hospital in Baghdad, Iraq. Methodology: Eighteen pediatric ALL patients were enrolled. Serum blood lipid profile, blood urea nitrogen (BUN), serum uric acid (UA), and serum creatinine levels were measured during treatment. Results: ALL was more among boys (61.11%) than girls. Of 18 cases, 14 (77.78%) were with low total cholesterol (TC), 2 (11.11%) with low triglycerides (TGs), all (100%) with low high-density-lipoprotein cholesterol (HDL-C), 14 (77.78%) with low blood urea nitrogen (BUN), and 2 (11.11%) with low serum uric acid (UA). Four (22.22%) were with high serum TGs, 6 (33.33%) with high serum very-low-density-lipoprotein (VLDL), 12 (66.67%) with high BUN, and 2 (11.11%) with high creatinine. Conclusions: Malignancies and chemotherapy recognizably affected serum lipid profile and serum renal function measurements and consequently adversely affected body. The specialist physician should be very careful in determining the dose of chemotherapy treatment, otherwise the specialist physician may be held accountable and accounting in case of serious damage to health or death of patients.