Salmonella enterica Encoding blaNDM Isolated at Saint-Camille Hospital in Ouagadougou, Burkina Faso

Abstract

Introduction: Salmonella enterica is a zoonotic pathogen of concern to human and animal health worldwide. Salmonellosis is responsible for significant morbidity and mortality and has a considerable global socioeconomic impact. With the aim of eradicating Salmonellosis caused by Salmonella enterica, we aimed to investigate multidrug resistance in NDM-type carbapenemase- producing S. enterica strains in patients received at HOSCO. Methodology: In the study, 278 Gram-negative bacilli were collected, including 18 strains of S. enterica. The DNA of the antibiotic-resistant strains was analyzed by conventional PCR for gene search blaNDM using specific primers. Results: The age group most affected by salmonellosis is 20 to 40 years. Thus, we observed a high resistance of 83% to Amoxiclav, 6% to Imipenem, 22% to Aztreonam, 11% to Meropenem and 17% to Ertapenem. Among the 18 strains of S. enterica 28 % coded for the blaNDM resistance gene. We note that the age group of [20; 40[ years was coded for blaNDM with a frequency of 17%. Also, 11% of S. enterica were multi-resistant. Conclusion: This study determined the frequency of S. enterica strains producing the NDM resistance enzyme. It also determined the multi-resistance of these strains, the frequency of which is 11%. This calls for increased vigilance in our strategies for combating salmonellosis.