Synergizing Bacteriophage Therapy and Computational Neuroscience: A Ray of Hope in the Fight against Antibiotic Resistance

Abstract

Antibiotic resistance presents an urgent and pervasive global health crisis that jeopardises human well-being. This dilemma primarily arises from the inappropriate and excessive use of antibiotics across diverse sectors, leading to the emergence of bacteria that have developed resistance to multiple medications. It is a matter of utmost concern due to its direct link to increased mortality rates and the disconcerting possibility of reverting to an era where antibiotics lose their effectiveness. This student experience paper delves into the potential of bacteriophage therapy as a remedy for antibiotic-resistant infections, a pressing issue emphasized by the National Health Service (NHS) in England. Building upon the recent first-hand experience of the first author while shadowing a General Medical Practitioner in Birmingham, UK, the study delves into critical facets of phage therapy. This exploration encompasses phage selection, formulation, delivery, and safety considerations. It also highlights the convergence with computational neuroscience, emphasizing the pivotal role of computational models in comprehending bacterial infections, antibiotic resistance, and neurological responses. This interdisciplinary approach underscores the necessity for collaborative efforts among microbiologists, healthcare professionals, and computational neuroscientists in addressing global healthcare challenges. Additionally, this experience sheds light on the practice of using antibiotics without a prescription, often for the treatment of infections that do not necessitate antibiotic intervention. This observation underscores the urgent requirement for stricter regulatory controls and an extensive educational program, both at the national and global levels.