Sanjay Kumar, Vijaya G. Tirunagaru, Jennifer Ariazi, Amit Awasthi, Venkatesh Babu Jayaraman, Premkumar Arumugam, Mahesh Yanamandra, Sayan Mitra, Sudhir Tiwari, Raghuram S. Tangirala, Thilo Werner, Douglas Thomson, Giovanna Bergamini & Mui Cheung·Journal of Pharmaceutical Research International·2017
Background and Aim: Acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) is a key enzyme catalyzing the final step of triglyceride (TG) synthesis and is implicated in fat absorption and disposition. However, development of several DGAT1 inhibitors has been hampered due to unaccepta...
Open access
Research Article10.9734/JPRI/2017/36835
Aims: Nanoparticle composites are a recent research hotspot, with the potential to be drug-delivery vehicles for more efficient treatment of malignant cancerous tumors. However, as this is a relatively new field, the safety of these nanoparticles is of concern. In this study, we...
Open access
Research Article10.9734/JPRI/2017/36154
Aim: The aim of this study was to improve solubility and dissolution characteristics of Ibuprofen using granulated fumed silica (Aeroperl®300) as a carrier. Methods: Ibuprofen-silica complex was prepared by solvent evaporation technique using ethanol as the solvent. Formulation I...
Open access
Research Article10.9734/JPRI/2017/36872
Objective: The objective of this work was the screening of different phytoconstituents and invitro antioxidant potential and α-glucosidase inhibitory activity of aerial parts of Fagopyrum tataricum. Methods: Preliminary phytochemical screening was performed by using standard prot...
Open access
Research Article10.9734/JPRI/2017/36067
Md. Najem Uddin, Md. Hafizur Rahman, Md. Mehedi Hasan, Md. Nazmul Islam, Md. Bokhtear Sarkar, Md. Rafiul Islam, S. M. Abdul Barik & Md. Nazmul Sardar·Journal of Pharmaceutical Research International·2017
Aims: It is a base line survey to find the reason behind the misuse of antibiotic in Bangladesh. Study Design: Questionnaires were supplied to corresponded persons to collect information from patient, doctors & pharmacy shop from seven region of Bangladesh. The data was analy...
Open access
Research Article10.9734/JPRI/2017/36672
Objective: To evaluate histomorphological, toxicological and antimicrobial activities of ethanolic extract of Calliandra portoricensis root in rodents. Introduction: C. portoricensis is usually administered for a lengthy period in treating diseases like dysmenorrheal, rheumatism...
Open access
Research Article10.9734/JPRI/2017/34701
The objective of this research was to studying the antibacterial activity of Portulaca oleracea L. in vitro cultures. P. oleracea leaves were collected from the local markets. Callus tissues were induced from the plant leaves (expalnt) through inoculating the explants on MS mediu...
Open access
Research Article10.9734/JPRI/2017/36071
The past few decades have seen a tremendous growth in the use of microneedles in the transdermal delivery of therapeutics. This is due to the several advantages that microneedles offer in the delivery of compounds. Therapeutics are delivered in a simple, minimally invasive and pa...
Open access
Research Article10.9734/JPRI/2017/36164
Aim: A new simple reversed phase high performance liquid chromatographic method was developed for the estimation of Atezolizumab in bulk and its injectable formulation. Study Design: Quantitative and qualitative estimation and degradation studies of AZM by using Rp-HPLC. Place an...
Open access
Research Article10.9734/JPRI/2017/35615
Senna occidentalis has been used in traditional medicine in Nigeria for managing various ailments in traditional medicine. This study was aimed at evaluating the central nervous system depressant effect of ethanol leaf extract of Senna occidentalis in mice. Thirty mice of either...
Open access
Research Article10.9734/JPRI/2017/25432