Misbahuddin M. Rafeeq, Ziaullah M. Sain, Norah A. Alturki, Ahmad Alzamami, Saeed A. Asiri, Mutaib M. Mashraqi, Amany I. Alqosaibi, Mashael M. Alnamshan, Abdulrahman Almutairi, Abdulkhaliq Munawir Alanazi & Qamre Alam·Journal of Pharmaceutical Research International·2021
Aromatase plays a significant role in the progression of estrogen receptor-positive (ER-positive) breast cancer. The adverse side effects of currently used aromatase inhibitors (AIs) necessitate the development of new AIs that are more active, selective, and less toxic. This stud...
Open access
Research Article10.9734/jpri/2021/v33i32A31717
Angiotensin is a hormone that plays a key role in the development of hypertension. Angiotensin-Converting Enzyme (ACE) inhibitors and Angiotensin Receptor Blockers (ARBs) are now the most often prescribed drugs to treat hypertension. The present in silico study involves exploring...
Open access
Research Article10.9734/jpri/2021/v33i32A31718
Objective: Current scientific investigations have evidenced that there is increased attention in developing novel drugs from bio source for the human health concern. This study's main objective was to intervene phytochemical constituents present in the ethanol leaf extract of an...
Open access
Research Article10.9734/jpri/2021/v33i32A31711
Dyslipidaemia an ever increasing menace emerging out of present lifestyle, is one of the major risk factors for developing Cardio-vascular abnormalities like Coronary Artery Disease (CAD), Myocardial infarction (MI), Cardiac arrest and is often associated with other metabolic dis...
Open access
Research Article10.9734/jpri/2021/v33i32A31713
Aims: Rheumatoid arthritis (RA) is characterized by the onset of oxidative stress. This study aimed to evaluate the enhancing of extra virgin olive (EVOO) and Evening primrose oil (EPO) on oxidative stress and liver enzymes in male Wistar rats and compare between them. Place and...
Open access
Research Article10.9734/jpri/2021/v33i32A31712
Background: Cancer is the world's second leading cause of death, accounting for an estimate of more than 10 million deaths annually. The most common type of cancers in women are breast, endometrial, cervical, ovarian, colorectal, lung, and skin cancers.Among these, breast cancer...
Open access
Research Article10.9734/jpri/2021/v33i31B31710
Aim: The aim of the present study was to design and evaluate solid lipid nanoparticles of Asenapine maleate (<2% bioavailability) to enhance its oral bioavailability and surface modification for brain targeting. Methods: A modified solvent injection method was used to produce...
Open access
Research Article10.9734/jpri/2021/v33i31B31706
Aims: The present application is a Newly Validated Reverse Phase-High Performance Liquid Chromatography Method for the Assay of Dexmethylphenidate and Serdexmethylphenidate with PDA. Study design: Mentioned study is a quick, rapid, economical, precise, and accurate reverse phase-...
Open access
Research Article10.9734/jpri/2021/v33i31B31707
Objective: This study was aimed to establish the prevalence of overweight, obesity and related its factors among the citizens of Karachi. Methodology: From Jan 2018 to August 2018. This cross-sectional analysis was conducted to obtain information from 772 persons using a validate...
Open access
Research Article10.9734/jpri/2021/v33i31B31708
Introduction: Metamemory awareness refers to our feelings or experiences of our own memory. For example, if a person feels certain that he or she will remember later something just learned now, that person is having a metamemory experience. Metamemory is a subarea of metacognitio...
Open access
Research Article10.9734/jpri/2021/v33i31B31709