β(1-3)(1-6)-D-glucans Modulate Immune Status and Blood Glucose Levels in Dogs
Vaclav Vetvicka, Carlos Oliveira
Journal of Pharmaceutical Research International · pp. 981–991 · Published 12 Mar 2014
10.9734/BJPR/2014/7862Abstract
Aims: The objective of this study is to evaluate the effects of adding two different glucans coded as BGO1 and BGO2 into commercial feed of dogs. Study Design: We measured changes in phagocytosis, levels of IL-2 in blood, antibody formation and level of blood sugar (normal homeostasis and experimentally-induced hyperglycaemie with streptozotocin). Place and Duration of Study: Department of Pathology, University of Louisville, and Department of Research and Development, Biorigin, June 2012 and May 2013. Methodology: The technique employing phagocytosis of synthetic polymeric microspheres was used for evaluation of phagocytic activity. IL-2 production was evaluated in serum by an ELISA kit. Formation of antibodies was tested using ovalbumin as an antigen, level of specific antibodies was measured by ELISA. Blood sugar evaluation was done both in normal animals and in animals with experimentally-induced hyperglycaemie. The level of glucose in serum was measured by Antech Diagnostics. Results: In phagocytosis, both glucans significantly (P ≤0.05 level) increased the phagocytic activity of blood monocytes and neutrophils. Both glucans were active in IL-2 tests, but BG01 activity was 160% of that of BG02. Similar data were achieved in evaluation of effects on antibody response – BG01 reached OD of 0.717, whereas BG02 reached OD 0.411. Blood sugar evaluations showed no effect of glucan on normal dogs, but significant (P ≤0.05 level) reduction in dogs with hyperglycaemie (both glucans showed same activity). Conclusion: Our data showed that both glucans had significant immunomodulating effects in immune reactions in the dog model, strongly suggesting that supplementation of feed with these glucans results in improvement of biological and immunological conditions of dogs.
Cited by 24
Po-Yun Teng, Chi-Huan Chung, Yun-Peng Chao · The Journal of Poultry Science · 2017
Renata Bacila Morais dos Santos de Souza, Eduarda Lorena Fernandes, Lorenna Nicole Araújo Santos · PLOS One · 2025
Marta Maturana, Lorena Castillejos, Susana M. Martin-Orue · Frontiers in Veterinary Science · 2023
J.C. Borosky, M.C.R. Costa, C.A.F. Oliveira · Arquivo Brasileiro de Medicina Veterinária e Zootecnia · 2023
Chayanne Silva Ferreira, Thiago Henrique Annibale Vendramini, Andressa Rodrigues Amaral · BMC Veterinary Research · 2022
Carlos A.F. de Oliveira, Vaclav Vetvicka, Fábio S. Zanuzzo · Comparative Immunology, Microbiology and Infectious Diseases · 2019
Panagiotis D. Tassis · Sustainable Use of Feed Additives in Livestock · 2023
Rafael Estevan Sabioni, Fábio Sabbadin Zanuzzo, José Eurico Possebon Cyrino · Brazilian Archives of Biology and Technology · 2019
Kristiina A. Vuori, Manal Hemida, Robin Moore · Scientific Reports · 2023
Rafael T. Alarcon, Katie J. Lamb, Gilbert Bannach · ChemSusChem · 2020
Showing 20 of 24 known citations — external sources report more than can currently be individually listed.
Related research
- First Trimester Fasting Blood Glucose as a Screening Tool for Diabetes Mellitus in a Teaching Hospital Setting in Nigeria — shares topic coverage
- Impact of the Diet Profile and Alcohol Consumption on Cardiometabolic Risks in Dschang Health District-Cameroon — shares topic coverage
- Effect of Aqueous Extract of Persea americana Seed on Blood Glucose in Alloxan-induced Diabetic Wistar Rats — shares topic coverage
- Metal Based α-glucosidase Inhibitors: Synthesis, Characterization and α-glucosidase Inhibition Activity of Transition Metal Complexes — shares topic coverage
- Evaluation of Fluid Therapy by Point-of-Care Ultrasound in Hyperglycemic Emergencies — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
24
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.