The Antibacterial Activity of 2-aminoindanbiguanide Chloride and Acetate Salts against Resistant Gram-negative Bacilli
Annual Research & Review in Biology · pp. 1353–1360 · Published 10 Jan 2014
10.9734/ARRB/2014/6807Abstract
Antiseptics and disinfectants are important substances for medical care. However, the needs for new antiseptics have increased in the last few years, due to multi-drug resistant pathogens. In this study we aimed to evaluate, the efficacy of 2-aminoindanbiguanide chloride (2-AIB.HCI) and 2-aminoindanbiguanideacetate (2-AIB.HOAc) salts that were synthesized against multi-drug resistant Gram-negative bacilli (MDR-GNB) (Acinetobacter spp, Escherichia coli and Klebsiella pneumoniae). According to our resultsat70 mg/mL concentrations of 2-AIB.HCI and 2-AIB.HOAc salts have been confirmed to be effective against hospital infection causing MDR-GNB. It was shown that 2-AIB.HCI and 2-AIB.HOAc salts have antibacterial efficacy against MDR-GNB.
References (19)
- 1 New polymeric biocides: synthesis and antibacterial activities of polycations with pendant biguanide groups [DOI]
- 2 Pharmacophoric Features of Biguanide Derivatives: An Electronic and Structural Analysis [DOI]
- 3 Antimicrobial dressing efficacy against mature Pseudomonas aeruginosa biofilm on porcine skin explants [DOI]
- 4 The effect of metformin on apoptosis in a breast cancer presurgical trial [DOI]
- 5 Complex Compounds of Biguanides and Guanylureas with Metallic Elements. [DOI]
- 6 The response of Escherichia coli to exposure to the biocide polyhexamethylene biguanide [DOI]
- 7 Multidrug-Resistant Gram-Negative Bacteria among Patients Who Require Chronic Hemodialysis [DOI]
- 8 Antidiabetic and antimalarial biguanide drugs are metal-interactive antiproteolytic agents [DOI]
- 9 Chemical Interaction of Alexidine and Sodium Hypochlorite [DOI]
- 10 Preparation of Chitosan Biguanidine Hydrochloride and Application in Antimicrobial Finish of Wool Fabric [DOI]
- 11 Biguanidines, gunaylureas and guanylthioureas [DOI]
- 12 Adiponectin and metformin additively attenuate IL1β-induced malignant potential of colon cancer [DOI]
- 13 In vitro comparison of the effectiveness of polihexanide and chlorhexidine against canine isolates of Staphylococcus pseudintermedius, Pseudomonas aeruginosa and Malassezia pachydermatis [DOI]
- 14 149. Synthetic antimalarials. Part X. Some aryl-diguanide (“-biguanide”) derivatives [DOI]
- 15 In vitro antiplaque properties of a series of alkyl bis(biguanides) [DOI]
- 16 Comparative evaluation of antibacterial property and substantivity of chlorhexidine containing dentifrices with sodium lauryl sulfate and Tween as surfactants: An in vivo study [DOI]
- 17 VIRUS INHIBITORY ACTIVITY OF BIGUANIDES AND RELATED COMPOUNDS [DOI]
- 18 Third-degree chemical burns from chlorhexidine local antisepsis.
- 19 Synthesis of some heterocyclic derivatives of biguanide with antibacterial activity [DOI]
Cited by 4
Hayriye Genç Bilgiçli, Ali Kestane, P. Taslimi · Bioorganic chemistry (Print) · 2019
Hayriye Genç, Mustafa Zengin, Aziz Öğütlü · Online Türk Sağlık Bilimleri Dergisi · 2017
Showing 2 of 4 known citations — external sources report more than can currently be individually listed.
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