Skip to content
Research Article Open access CC BY 3.0

The Antibacterial Activity of 2-aminoindanbiguanide Chloride and Acetate Salts against Resistant Gram-negative Bacilli

Hayriye Genç, OÄŸuz Karabay

Annual Research & Review in Biology · pp. 1353–1360 · Published 10 Jan 2014

10.9734/ARRB/2014/6807

Abstract

Antiseptics and disinfectants are important substances for medical care. However, the needs for new antiseptics have increased in the last few years, due to multi-drug resistant pathogens. In this study we aimed to evaluate, the efficacy of 2-aminoindanbiguanide chloride (2-AIB.HCI) and 2-aminoindanbiguanideacetate (2-AIB.HOAc) salts that were synthesized against multi-drug resistant Gram-negative bacilli (MDR-GNB) (Acinetobacter spp, Escherichia coli and Klebsiella pneumoniae). According to our resultsat70 mg/mL concentrations of 2-AIB.HCI and 2-AIB.HOAc salts have been confirmed to be effective against hospital infection causing MDR-GNB. It was shown that 2-AIB.HCI and 2-AIB.HOAc salts have antibacterial efficacy against MDR-GNB.

Multi-drugresistantbacteria disinfectant disinfection 2-aminoindanbiguanide salts.

References (19)

  1. 1 New polymeric biocides: synthesis and antibacterial activities of polycations with pendant biguanide groups [DOI]
  2. 2 Pharmacophoric Features of Biguanide Derivatives: An Electronic and Structural Analysis [DOI]
  3. 3 Antimicrobial dressing efficacy against mature Pseudomonas aeruginosa biofilm on porcine skin explants [DOI]
  4. 4 The effect of metformin on apoptosis in a breast cancer presurgical trial [DOI]
  5. 5 Complex Compounds of Biguanides and Guanylureas with Metallic Elements. [DOI]
  6. 6 The response of Escherichia coli to exposure to the biocide polyhexamethylene biguanide [DOI]
  7. 7 Multidrug-Resistant Gram-Negative Bacteria among Patients Who Require Chronic Hemodialysis [DOI]
  8. 8 Antidiabetic and antimalarial biguanide drugs are metal-interactive antiproteolytic agents [DOI]
  9. 9 Chemical Interaction of Alexidine and Sodium Hypochlorite [DOI]
  10. 10 Preparation of Chitosan Biguanidine Hydrochloride and Application in Antimicrobial Finish of Wool Fabric [DOI]
  11. 11 Biguanidines, gunaylureas and guanylthioureas [DOI]
  12. 12 Adiponectin and metformin additively attenuate IL1β-induced malignant potential of colon cancer [DOI]
  13. 13 In vitro comparison of the effectiveness of polihexanide and chlorhexidine against canine isolates of Staphylococcus pseudintermedius, Pseudomonas aeruginosa and Malassezia pachydermatis [DOI]
  14. 14 149. Synthetic antimalarials. Part X. Some aryl-diguanide (“-biguanide”) derivatives [DOI]
  15. 15 In vitro antiplaque properties of a series of alkyl bis(biguanides) [DOI]
  16. 16 Comparative evaluation of antibacterial property and substantivity of chlorhexidine containing dentifrices with sodium lauryl sulfate and Tween as surfactants: An in vivo study [DOI]
  17. 17 VIRUS INHIBITORY ACTIVITY OF BIGUANIDES AND RELATED COMPOUNDS [DOI]
  18. 18 Third-degree chemical burns from chlorhexidine local antisepsis.
  19. 19 Synthesis of some heterocyclic derivatives of biguanide with antibacterial activity [DOI]

Cited by 4

Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials.

Hayriye Genç Bilgiçli, Ali Kestane, P. Taslimi · Bioorganic chemistry (Print) · 2019

Showing 2 of 4 known citations — external sources report more than can currently be individually listed.

Article metrics

Real usage data collected on this platform.

45

Page views

0

PDF downloads

17

Outbound clicks

4

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.