Aims: To demonstrate the efficacy of aromatic hydrazide compounds to inhibit growth of Mycobacterium tuberculosis. Study Design: To synthesize tuberculostats and test their antibacterial activity in-vitro. Place and Duration of Study: University of Nebraska, Durham Science Center...
Open access
Research Article10.9734/jamps/2019/v21i430148
Aims: To determine the influence of molecular properties upon the effectiveness of four peptide compounds to inhibit growth of Escherichia coli and show the potential of small molecule peptide drugs. Study Design: Examine molecular properties and extent of bacterial inhibition. U...
Open access
Research Article10.9734/JAMPS/2018/41548
Zinc is an essential mineral that can cause pathological effects whether in excess or deficiency. Zinc is a component for over 250 enzymes and is required for cell growth, cell division, and cell function. Zinc is found in muscle and bones, with the prostrate, liver, skin, and k...
Open access
Research Article10.9734/EJNFS/2017/35783
Aims: To determine the molecular properties of common antihistamines and non-steroidal anti-inflammatory agents (NSAIDs). To identify interrelationships among these two groups of drugs utilizing pattern recognition methods and statistical analysis. Study Design: After determinati...
Open access
Research Article10.9734/JAMPS/2017/32695
Aims: To examine the properties of hydrazide compounds shown to inhibit Mycobacterium tuberculosis. To identify properties that affect efficiency of bacterial inhibition. Study Design: Utilizing data from previous studies of compounds that inhibit Mycobacterium tuberculosis, then...
Open access
Research Article10.9734/JAMPS/2016/30855
Aims: To demonstrate that potassium ferrate will remove potentially toxic metal ions from contaminated water samples. Study Design: A known amount of metal ions were solubilized in aqueous solution, then exposed to potassium ferrate in known amounts. Extent of removal was monitor...
Open access
Research Article10.9734/BJECC/2016/26273
Aims: To demonstrate an analysis for vitamin B6 from commercial aqueous nutritional drinks and solid tablets, utilizing isocratic conditions with high performance liquid chromatography (HPLC) and UV detection at 290 nm. Study Design: Vitamin B6 in the form of pyridoxine hydrochlo...
Open access
Research Article10.9734/JSRR/2016/28991
Aims: To present the molecular structures of compounds that has been shown to inhibit the proliferation of Ebola virus. To elucidate the molecular properties of these virus inhibiting compounds. Study Design: The molecular properties of virus inhibiting compounds are elucidated a...
Open access
Research Article10.9734/IJTDH/2016/25021
Aims: To demonstrate the efficacy of several small molecular weight compounds having hydrazide groups, for inhibiting the growth of Mycobacterium tuberculosis. To show these same compounds have favorable drug-likeness properties. Study Design: To synthesize tuberculostats and te...
Open access
Research Article10.9734/JAMPS/2016/24351
Aims: To synthesize small molecule alkylating compounds and analyze the kinetics of the alkylation in aqueous solution. Determine molecular properties and the drug likeness of these four compounds as potential antineoplastic agents and apply statistical analysis to identify inter...
Open access
Research Article10.9734/ACRI/2015/19813
Aims: To identify isosteres and bioisosteres suitable for substitution on the molecular scaffold of meclofenamic acid and tolfenamic acid. The compounds will be studied to determine drug-likeness and other properties. Study Design: Isosteres and bioisosteres were selected and emp...
Open access
Research Article10.9734/JAMPS/2015/18954
Aims: To present 12 new variants of uracil mustard having drug-like properties and cytotoxic functional group, by utilizing uracil mustard (uramustine) as a lead compound. Utilize rigorous substructure and similarity of a molecular scaffold to determine drug like variants. Physic...
Open access
Research Article10.9734/JCTI/2015/17780
Aims: Foods are analyzed for their content for important reasons that include: Adherence to government regulations, nutritional labeling, authentication, inspection (for grading), safety, quality control and detection of adulterants. Study Design: Inductively coupled plasma mass...
Open access
Research Article10.9734/AIR/2015/13579
Aims: The permeability coefficient, or Kp, is an important descriptor for assessing dermal absorption of medicaments utilized for clinical treatment of various dermal accessible diseases. Determination of Kp by multiple descriptors by artificial neural network (ANN) and multiple...
Open access
Research Article10.9734/JSRR/2014/13125
Aims: To evaluate the efficacy of two alkylating structural analogues of chloramphenicol that have potential for application for treatment of dermal sited neoplasms. Study Design: Two compounds have been shown to alkylate guanosine-5’-diphosphate (GDP) at physiological conditions...
Open access
Research Article10.9734/JAMPS/2014/11838
Aims: To demonstrate the efficacy of five small molecule compounds for inhibiting the growth of Mycobacterium tuberculosis. To present evidence that these compounds will penetrate into the central nervous system. Study Design: Five small molecule compounds bearing a hydrazide gro...
Open access
Research Article10.9734/BJPR/2014/10353
Aims: The aim of this work is to present the findings of various studies relevant to the incidence of sexually transmitted disease (STD) among women who have sex with women (WSW). This being an important issue when considering the numerous and diverse types of infections possible...
Open access
Research Article10.9734/ISRR/2014/8931
Aims: Riboflavin is a B vitamin that is required for a wide variety of cellular processes. The absorbance spectrum of riboflavin was determined at different pH utilizing several buffers. The buffer at pH demonstrating stable absorbance peaks with high numerical values of molar ab...
Open access
Research Article10.9734/JSRR/2014/8598
Aims: Brain and spinal cord tumors are the third most common type of childhood cancer following leukemia and lymphoma. Mechlorethamine (or mustine) is a nitrogen mustard antineoplastic drug. Eleven variants of mechlorethamine are presented that possess molecular properties enabli...
Open access
Research Article10.9734/BJPR/2013/5761