Leonard Ona Ehigie

In-vivo Anti-Plasmodial Activity of Enantia chlorantha: A Potential Plasmodium berghei Survival Inhibitor

Rashida Saheed-Alimi, Suleiman Adebayo Nassir, Leonard Ona Ehigie, Kikelomo Olayemi Oyeleke, Caleb Oladele Adegoke & Amudalat Adedokun · International Journal of Pathogen Research · 2024

The emergence of resistance to existing antimalarial drugs has intensified the search for novel, effective, and affordable treatments for malaria. The sensitivity of strains of Plasmodium spp. to the commonly known antimalarial drugs over time undermines the effectiveness of trea...

Open access Research Article 10.9734/ijpr/2024/v13i6332

Effect of Hexane Extracts of Chromolaena odorata (Linn.) on Hematotoxicity Induced by Cyanide in Male Albino Wistar Rats

Fiyinfoluwa Demilade Ojeniyi, Adeola Folashade Ehigie, Aluko Oluwatosin Lydia, Gbadebo Emmanuel Adeleke & Leonard Ona Ehigie · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2021

Aim: To investigate the effect of Hexane extract of Chromolaena odorata (HECO) on cyanide induced hematotoxicity in male Albino Wistar rats. Methodology: Thirty-five (35) male albino rats weighing between 100g and 150g were distributed randomly into 7 groups of 5 rats each. Group...

Open access Research Article 10.9734/ajbgmb/2021/v9i230214

Computational Evaluation of Some Schiff-Bases of Phenylisocytosine as Potent Inhibitors of Plasmodium falciparum Transketolase in Anti-Malarial Drug Discovery

Opeyemi Emmanuel Atanda, Adeola Folasade Ehigie, Tawakalit Abimbola Adisa, Lamidi Waheed Babatunde Olaniyan, Temitope Tunji Odunitan, Olatomide Ayodeji Fadare, Mary Oyindamola Jesulade, Adedamola Onikepo Adesina & Leonard Ona Ehigie · International Journal of Biochemistry Research & Review · 2025

Background: The increasing prevalence of drug-resistant Plasmodium falciparum strains, particularly resistance to frontline therapies such as artemisinin and its derivatives, poses a significant challenge to malaria control and eradication efforts. This necessitates the developme...

Open access Research Article 10.9734/ijbcrr/2025/v34i41021

In-Silico Evaluation of Phenylisocytosine and Its Analogs as Potent Inhibitors of Plasmodium Falciparum Transketolase: A Strategic Approach in Anti-Malarial Drug Discovery

Opeyemi Emmanuel Atanda, Lamidi Waheed Babatunde Olaniyan, Olatomide Ayodeji Fadare, Adeola Folasade Ehigie, Tawakalit Abimbola Adisa, Temitope Tunji Odunitan, Oluwabunmi Temitope Alabi, Bukola Adeola Omonijo, Aloba Gideon Oluwaseun & Leonard Ona Ehigie · International Journal of Biochemistry Research & Review · 2024

Background: The rise of drug-resistant Plasmodium falciparum strains, particularly those resistant to artemisinin-based combination therapies (ACTs), underscores the urgent need for alternative antimalarial agents targeting novel biochemical pathways. Aim: This study investigates...

Open access Research Article 10.9734/ijbcrr/2024/v33i6941