Lawrence John AJutor, Edibokun Theresa Orobator, Blessing Ben- Anioke, Victor Chiedozie Ezeamii, Mayowa Josiah Badmus, Uchechi Ngozichukwu Obiefule, Vincent Barrah, Mary Oluwabunmi Oyebode & Josiah Stephen·Journal of Cancer and Tumor International·2025
BRCA1 and BRCA2 genes, located on separate chromosomes, encode crucial multifunctional proteins that are important for correcting errors in DNA replication and cell division. The two genes work in tandem at different stages in the DNA damage response and for DNA repair and could...
Open access
Research Article10.9734/jcti/2025/v15i2296
Lawrence John AJutor, Henry Edafe Golor, Caleb Otabil, Bianca Victor Egbosimba, Olutayo Nathanael Farinde, Adedapo Olosunde, Tobi David Farinde & Stephen Atta-Fynn·International STD Research & Reviews·2025
Sexual health behaviours among young adults are influenced by multiple factors, including digital media exposure, parental communication, and peer influence. The increasing reliance on digital platforms for sexual health information, the role of parental guidance, and the impact...
Open access
Research Article10.9734/ISRR/2025/v14i1186
Lawrence John AJutor, Olutayo Nathanael Farinde, Edibokun Theresa Orobator, Toluwanimi Janet Kolapo, Izuchukwu Gerald Ezema, Victor Damilare Oladele, Tobi David Farinde, Adedapo Olosunde, Peace Godwin Monday & Ayomide Babatunde Ishola·International Research Journal of Oncology·2025
Non-small cell lung cancer (NSCLC) is regarded as the most prevalent form of lung cancer, accounting for approximately 85% of all cases worldwide. This type of cancer is highly affected by the tumour microenvironment (TME), where exosomal communication is a major contributor. Thi...
Open access
Research Article10.9734/irjo/2025/v8i1173
Lawrence John AJutor, Blessing Aitebiereme Iyoyojie, Kingsley Ugonna Ugoagwu, Orkaa Terungwa Samuel, Olufemi Adesola Adedayo, Daniel Temiloluwa Oyedemi, Daniel Ebubechi Obasi, Adegbesan Abiodun Christopher, Adewoyin Peter Bemigho & Christian Ajiri Adobor·International Research Journal of Oncology·2025
Triple-negative breast cancer (TNBC) is one of the most prominent types of breast cancer. It is a very aggressive subtype that is characterized by the absence of certain receptors which are expected on the surface of tumor cells. Limited treatment options and a poor prognosis, hi...
Open access
Research Article10.9734/irjo/2025/v8i1170
Lawrence John AJutor, Fatima Bello Sani, Elijah Nehemiah Kama, Kingsley Ugonna Ugoagwu, Adegbesan Abiodun Christopher, Daniel Temiloluwa Oyedemi, Peter Bemigho Adewoyin, Olayinka Esther Agbetanmije, Adepeju Matilda Adekoya & Erere Godsent Onyeugbo·Journal of Cancer and Tumor International·2025
Bioelectrical signals which are directed by ion channels and membrane potential (V_mem), play a crucial role in many cellular processes including proliferation and differentiation. It has also been known to influence processes such as gene expression, epigenetics, and tumor progr...
Open access
Research Article10.9734/jcti/2025/v15i1280
Lawrence John AJutor, Okabeonye Sunday Agbo, Christian Ajiri Adobor, Blessing Aitebiereme Iyoyojie, Kingsley Ugonna Ugoagwu, Oghenevware Manawa, Osaruese Faluyi, Emmanuel Oluwasegun Ismaila, Oluchi Esther Ugwuanyi & Adepeju Matilda Adekoya·Asian Journal of Biochemistry, Genetics and Molecular Biology·2024
Gene editing has emerged as a transformative approach in cancer immunotherapy. Several gene editing tools have been employed for precise modification of the DNA of immune cells, enhancing their ability to target and eliminate cancer cells. This review examines the evolution and a...
Open access
Research Article10.9734/ajbgmb/2024/v16i12428
Oluwatobiloba Kehinde Adedokun, Temitope Emmanuel Alo, Kazeem Olanrewaju Bankole, Modinat Aina, Abayomi, Nanmet Ephraim Panwal, Jeremiah Tella & Lawrence John AJutor·International Research Journal of Oncology·2025
While genetic mutations are well-known triggers for leukaemia, inflammation plays a big part by messing with cell growth and immune responses, yet its complex patterns are hard to track with traditional methods. This review looks at how artificial intelligence (AI) and machine le...
Open access
Research Article10.9734/irjo/2025/v8i2185
Salvation Ifechukwude Atalor, Jumoke Ologun, Modinat Aina, Abayomi, Obiageri Ihuarulam Okeoma, Opeoluwa Alayande, Awah Favour Matthew, Reginald Oyortey & Lawrence John AJutor·International Research Journal of Oncology·2025
Gene editing technologies have revolutionized the approach to treating cancer by enabling precise modifications to the genome, particularly through programmable chromosome engineering techniques that allow for large-scale rearrangements, deletions, and insertions to correct or di...
Open access
Research Article10.9734/irjo/2025/v8i2187
Fortune Itoje Ebiala, Jumoke Ologun, John Kelenna Iregbu, Ogochi Blessing Chukwuneke, Aliaa Mohammed Mahmoud Soliman, Ayo Ebunolorun Ibukunoluwa, Rasheedat A. Busari MD, Oluwatobiloba Kehinde Adedokun & Lawrence John AJutor·Journal of Cancer and Tumor International·2025
Background: Oncogene addiction occurs in most tumour cells it is a phenomenon capable of driving colorectal cancer (CRC) growth, where tumour cells rely on genes like KRAS, BRAF, or MYC to survive. This has been so far seen as an exploitable target for precision therapies. Aim: T...
Open access
Research Article10.9734/jcti/2025/v15i3316
Josiah Stephen, Ikechukwu Kanu, Nwamaka Nneka Onyedum, Edibokun Theresa Orobator, Catherine Rono, Ngwoke, Chinaza Faith, Victor Omeiza David, Wonderful Oluwatoyin Anosike & Lawrence John AJutor·Journal of Cancer and Tumor International·2025
HLA class I molecules are essential for presenting tumour antigens to cytotoxic T-cells, but their dysregulation in cancer enables immune evasion and limiting the efficacy of immunotherapies for cancer. The objective of this review is to explore the function of HLA class I change...
Open access
Research Article10.9734/jcti/2025/v15i3299
Habib Olaniran Kolawole, Edibokun Theresa Orobator, Blessing Imade, Victor Damilare Oladele, Ezema Izuchukwu Gerald, Kamsiyochukwu Anita Ezeani, Daniel Ebubechi Obasi, Adegbesan Abiodun Christopher, Peter Bemigho Adewoyin & Lawrence John AJutor·Journal of Cancer and Tumor International·2025
There has been an increase in the amount of studies focusing on the relevance of tumour microenvironment (TME) in metastasis of breast cancer. Cancer-associated fibroblasts (CAFs) is one of the most abundant cells found in the TME that play key roles in the metastasis of cancers...
Open access
Research Article10.9734/jcti/2025/v15i2288