Jack Fruit: An Estimation of Hunteria Umbellata Fruit Extract against Formalin Induced Nociception

Abstract

The purpose of the study is to ascertain the impact of ethanolic fruit extract from Hunteria umbellata on formalin-induced nociception in Wistar rats. Six sets of thirty Wistar rats, weighing 110.7 to 169.4 g each, were employed for the investigation. Group 1 functioned as the control group and was given nothing except unlimited amounts of rat food and water. Formalin was administered just to Group 2, which served as the FOG. Group 3 rats were given the standard drug group (SDG). Group 4 rats received 50 mg of Hunteria umbellata fruit extract per kilogramme of body weight. Group 5 rats received 100 mg of Hunteria umbellata fruit extract per kilogramme of body weight. Group 6 rats received 150 mg of Hunteria umbellata fruit extract per kilogramme of body weight. The experimental rats were given 50L of a 2% formaldehyde solution subcutaneously into their left hind paws an hour after extract and medication administration in order to cause pain. The duration of paw licking was immediately used to identify the spontaneous nociceptive behaviour. Following a 14-day period of treatment, samples were taken and tested for signs of pain. The significance level was set at p 0.05 after post hoc LSD and SPSS analysis of the data. The outcome showed that, in contrast to the formalin only group, the extract (LDEG, MDEG, HDEG) significantly enhanced (p0.05) the reaction time of nociceptive behaviours (FOG). In contrast to the control group, serum nociceptive molecules considerably (p 0.05) increased in the formalin only group (FOG). In conclusion, the extract proved useful for treating nociception by traditional medical professionals (herbalists).