In postmenopausal women, a substantial decrease in circulating estrogen levels has been strongly associated with an increased risk of cognitive dysfunction. Both clinical and preclinical studies have demonstrated that estrogen positively affects synaptic plasticity, hippocampal n...
Open access
Research Article10.9734/ajrimps/2025/v14i3340
Plant-drug interactions mediated by cytochrome P450 (CYP450) enzymes are a critical area of study owing to their potential to alter drug metabolism, efficacy, and toxicity. This review examines how common phytochemicals such as flavonoids, polyphenols, alkaloids, and terpenes mod...
Open access
Research Article10.9734/jamps/2025/v27i8808
Momordica charantia (bitter melon) is a tropical vine with a long history in traditional medicine. Recent studies have focused on its therapeutic applications, particularly for diabetes, metabolic syndrome, and polycystic ovary syndrome (PCOS). The plant contains bioactive compou...
Open access
Research Article10.9734/jocamr/2025/v26i8688
Paul Chinwuba, Chimaobi O. Ugorji, Daniel L. Ajaghaku, Winifred O. Amattah, Amara A. Ajaghaku, Onyesife C. Obiageli, Zogini U. Confidence, Victor T. Ezeifeh & Okoro O. Kingsley·Journal of Pharmaceutical Research International·2025
Neuroinflammation driven by the NLRP3 inflammasome is a key mechanism in many neurological disorders. While plant-derived polyphenols and terpenoids individually show anti-inflammatory potential, their synergistic effects remain underexplored. This review highlights the enhanced...
Open access
Research Article10.9734/jpri/2025/v37i117762
Aim: The antidotal potential of Hippocratea africana root, which is used locally to cure poisoning, was studied in rats. Methodology: The hepatoprotective activity of the root extract (200-600 mg/kg), fractions (dichloromethane (DCM) and aqueous, 400 mg/kg) and Silymarin (100 mg/...
Open access
Research Article10.9734/ajbgmb/2023/v15i3344
Oxidative stress plays an important role in both induction of diabetes and development of diabetes complications. This study evaluated the effect of leaf extract and fractions of M. cecropioides on both chemical and disease induced oxidative stress. The leaves were extracted with...
Open access
Research Article10.9734/jsrr/2022/v28i121718