Platelet concentrates (PCs) are widely used in transfusion medicine for therapeutic purposes and their demand is constantly on the rise. Current storage regulations make this product highly susceptible to bacterial contaminations and platelet storage lesions (PSL) causing the nee...
Open access
Research Article10.9734/ibrr/2023/v14i4318
Introduction: Glioblastoma multiforme (GBM) has a poor prognosis despite optimal treatment. Recent studies have shown the potential of phytochemicals as anti-cancer agents. α-solanine, derived from plants of the Solanum genus, is a promising molecule in this regard. This study in...
Open access
Research Article10.9734/jpri/2023/v35i207402
Glioblastoma multiforme (GBM) is the most prevalent primary malignant central nervous system tumours (CNST). Current treatment consists of surgical resection and adjuvant chemoradiotherapy, the gold-standard agent being Temozolomide (TMZ). Despite optimal treatment, GBM has an ab...
Open access
Research Article10.9734/jocamr/2023/v21i1427
Platelets are small anucleate cell fragments found in the blood, which originate from large cells known as megakaryocytes. Platelets are widely used in transfusion medicine for therapeutic purposes. Platelet transfusions are beneficial for patients who are experiencing thrombocyt...
Aims: The necessity for Platelet Concentrates (PCs) in transfusion has increased, and several measures have been undertaken to try and increase the shelf-life of this product. Increasing the shelf-life to 10 days from the current 5 days will increase availability and reduce waste...
Open access
Research Article10.9734/jammr/2022/v34i2131553
Aging is becoming one of the biggest burdens to the developed world, mainly due to it being linked to a variety of diseases from neurodegenerative disorders such as Alzheimer’s disease to cancer. It involves the dysregulation of virtually every biological process known, affecting...
Open access
Research Article10.9734/ibrr/2022/v13i430185
The rapid advancement in research technologies and bioinformatics over the past few decades has enabled researchers to shed light on the underlying mechanisms behind aging. Whilst the progress in understanding the biochemical processes involved is impressive, a lot more still nee...
Open access
Research Article10.9734/jammr/2021/v33i2131152
Storage lesions of blood products intended for transfusion have been shown to give rise to the accumulation of proin flammatory cytokines, which are known to cause transfusion associated adverse events and immunomodulatory effects. Regulations which determine the eligibility of b...
Open access
Research Article10.9734/jammr/2021/v33i2431239