Farida Jazuli Usman, Dikshat Gopal Gupta, Sarki A Abdulkadir, Ibrahim Muhammad Usman, Adamu Jibrin Alhassan, Young A Yoo, Haris Jaafar Bello, Binta G. Kurfi & Kamaluddeen Babagana·Asian Journal of Biochemistry, Genetics and Molecular Biology·2025
Despite advancements in the treatment of advanced prostate cancer, including metastatic castration-resistant prostate cancer (mCRPC), the disease remains lethal, often developing resistance to conventional therapies such as androgen deprivation therapy (ADT) and chemotherapy. The...
Open access
Research Article10.9734/ajbgmb/2025/v17i1434
Introduction: Cancers are a real public health problem. Their prevalence varies greatly among the world population and many therapeutic strategies, such as chemotherapy, have been put in place and most chemotherapy protocols are based on products containing fluoropyrimidines. How...
Open access
Research Article10.9734/ajbgmb/2025/v17i1433
Anti-retroviral (ARV) drugs are medications used for the treatment of diseases caused by retroviruses, primarily HIV. HIV/AIDS is a condition in human in which the immune system starts to fail, resulting to life threatening opportunistic infections. This study investigated the ef...
Open access
Research Article10.9734/ajbgmb/2025/v17i1432
Testosterone plays a crucial role in various aspects of reproductive health and general well-being. Herbal extracts are commonly believed to have potential effects on testosterone levels. This study aimed to explore the impact of hot aqueous extracts of Cyperus esculentus latvum...
Open access
Research Article10.9734/ajbgmb/2024/v16i12430
HIV/AIDS is a condition in human in which the immune system begins to fail, leading to life threatening opportunistic infections. This study investigated the effect of first and second line fixed-dose combination (FDC) antiretroviral drugs on some biochemical parameters in Wistar...
Open access
Research Article10.9734/ajbgmb/2024/v16i12431
Testosterone influences various aspects of reproductive health and overall well-being. Herbal extracts are reputed for their potential effects on testosterone levels. This study investigated the testosterone-modulating potentials of hot aqueous extracts of Telfairia occidentalis...
Open access
Research Article10.9734/ajbgmb/2024/v16i12429
Lawrence John AJutor, Okabeonye Sunday Agbo, Christian Ajiri Adobor, Blessing Aitebiereme Iyoyojie, Kingsley Ugonna Ugoagwu, Oghenevware Manawa, Osaruese Faluyi, Emmanuel Oluwasegun Ismaila, Oluchi Esther Ugwuanyi & Adepeju Matilda Adekoya·Asian Journal of Biochemistry, Genetics and Molecular Biology·2024
Gene editing has emerged as a transformative approach in cancer immunotherapy. Several gene editing tools have been employed for precise modification of the DNA of immune cells, enhancing their ability to target and eliminate cancer cells. This review examines the evolution and a...
Open access
Research Article10.9734/ajbgmb/2024/v16i12428
Aim: To evaluate Single Nucleotide Polymorphism and Allele frequencies of some genetic variants among T2DM subjects in Port Harcourt. Study Design: Cross-sectional Study. Place and Duration of Study: Port-Harcourt, Nigeria, Inqaba Biotec (molecular analysis) and Evashalom Medical...
Open access
Research Article10.9734/ajbgmb/2024/v16i12426
Aim: To evaluate the influence of some variants of SLC22A1 and CYP2C9 genes on glycaemic response in T2DM subjects on metformin/Sulphonylureas combination therapy in Port Harcourt. Study Design: Cross-sectional Study. Place and Duration of Study: Port-Harcourt, Nigeria, Inqaba Bi...
Open access
Research Article10.9734/ajbgmb/2024/v16i12427
Background: Pigeon pea is an economical source of natural antioxidants and its use could be a means of attaining prospect in ensuring food safety. This in vitro study intends to compare the primary constituents and oxidation inhibition potentials of peeled pigeon pea (PPP) and un...
Open access
Research Article10.9734/ajbgmb/2024/v16i12424
Maryann Nonye Nwafor, Emenike Benjamin Amadi, Alalibo Jim Whyte, Nkechinyere Florence Godwin, Uduakobong Olufunso Abosede, Chinedu Shedrack Ogunwa, Michael Obinna Eji & Abba Babandi·Asian Journal of Biochemistry, Genetics and Molecular Biology·2024
The fruit,Tetrapleura tetraptera belongs to the Mimosaceae family and is widely used in traditional remedies for the treatment of diseases and a popular seasoning spice in southern and Eastern Nigeria. The present study investigated the proximate analysis, phytochemical compositi...
Open access
Research Article10.9734/ajbgmb/2024/v16i12425
Aim: To assess the levels of heavy metals (cadmium, lead, chromium, copper), and pH in periwinkles, whelks, oysters, sediment, and water found in some swamps in Rivers State. Study Design: Analytical Cross-sectional study. Place and Duration of Study: Borokiri, Trans-Amadi, Eagle...
Open access
Research Article10.9734/ajbgmb/2024/v16i12423
Angela Chinenye Ogbu, Okpaga Austine Ume, Olando Cletus Nwogiji, Samson Olumide Akeredolu, Ofobuike Godson Eze, Chikezie Victor Onwe, Oluwasegun Ifeoluwa Oduguwa & Uchenna Victor Chigozie·Asian Journal of Biochemistry, Genetics and Molecular Biology·2024
Africa is grappling with various challenges, particularly in agricultural production and disease prevention affecting humans, animals, and crops. Gene editing, or genome editing (GE), involves modifying, adding, or removing nearly any DNA sequence in various cells and organisms....
Open access
Research Article10.9734/ajbgmb/2024/v16i12422
Tyas Anggraini, Slamet Isworo, Enny Rachmani, Cynthia Arsita, Rahel Amanda Konoralma, Andreas Wilson Setiawan, Lely Kusumaningrum, Surya Ayu Pratiwi, Daffa Zaedan Hanif, Iksa Yoda Paksi & Ni Komang Widnyan·Asian Journal of Biochemistry, Genetics and Molecular Biology·2024
Background and Objective: Sudden weight loss is a potential early indicator of metabolic disorders commonly associated with diabetes, although its role in the early detection of the disease has not been extensively studied. Therefore, further exploration is needed to evaluate whe...
Open access
Research Article10.9734/ajbgmb/2024/v16i12421
Possible Okikiola Popoola, Ogechi Cecilia Ofor, Chinasa Godsgift Eni, Christian Albert Agyei-Acheampong, Chinedum Ojinaka Okafor, Emmanuel Niyi Olowe, Adnan Musa, Oluwatoyin Olabimpe Olofin, Sandra Ngozika Offor & Tosin Olaniran·Asian Journal of Biochemistry, Genetics and Molecular Biology·2024
Melatonin and pregabalin are two important compounds that are broadly used in the fields of physiological and medicinal sciences. Melatonin is a primary hormone mainly secreted by the pineal gland and plays an important role in regulating circadian rhythms, sleep-wake cycles, and...
Open access
Research Article10.9734/ajbgmb/2024/v16i12420