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Interaction of Antimalarial Drug, Pyrimethamine and Sulphadoxine with Sickle Haemoglobin at pH 5.0 and pH 7.2: A Fourier Transform Infrared (FTIR) Study

A. E. Amalunweze, A. L. Ezugwu, S. O. O. Eze & F. C. Chilaka · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2022

Aggregation of sickle haemoglobin (HbS), upon deoxygenation, is responsible for an inherited genetic disorder in the human red blood cells (RBCs) known as Sickle cell disease (SCD). On the suggestion that this phenomenon could arise from some form of conformational changes in the...

Open access Research Article 10.9734/ajbgmb/2022/v10i230243

Effect of Coadministration of Lambda Cyhalothrin and Different Local Spices on Testicular Histology in Swiss Mice

Adetutu Olubunmi Obulor, Eme Efioanwan Orlu & Martina Toritse Veronica Adeleke · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2022

Aim: This study was aimed at evaluating the effect of coadministration of lambda cyhalothrin and different local spices on testicular histology in Swiss mice Experimental Design: A completely randomized experimental design using standard methods for analysis. Location and Duratio...

Open access Research Article 10.9734/ajbgmb/2022/v10i230242

Evaluation of Zinc Status and Socio-Economic Profile of Pregnant Women in Osogbo Metropolis, South-Western Nigeria

OLAYIWOLA Kehinde Olamide, AYODELE Ifeoluwa Aderonke, OLANIYAN Adebola Oluwapolola & Iyanda Ayobola Abolape · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2022

Purpose: Zinc status during gestation affects both maternal and fetal health. The study was designed to investigate maternal zinc status and relate it with dietary zinc and socioeconomic levels in first, second and third trimester pregnant women. Methods/Patients: Forty-five [15...

Open access Research Article 10.9734/ajbgmb/2022/v10i230241

Dopamine’s Role in Psychopathology and Biochemistry of Brain

Pouya Pournamdar, Pooneh Azadi, Mir Mahmoud Seyyed Valilou & Niloufar Oliaei · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2022

Dopamine (dihydroxyphenethylamine) is an organic compound from the family of Catecholamines and Phenylamines and plays an important role in the brain functioning. Dopamine is synthesized by precursors in the kidneys and brain. Dopamine is among the essential neurotransmitters in...

Open access Research Article 10.9734/ajbgmb/2022/v10i230240

Analgesic Properties of Aqueous Leaf Extract of Alchornea cordifolia (Christmas Bush) on Wistar Rats

E. Harrison Ogheneochuko, Dikoye Peters, C. Awarajih Uwaezuoke & Ukoro Blessing · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2022

Disease conditions leading to pain are major healthcare problem worldwide. Incidences of pain related disorders have been on the increase worldwide. Although, several synthetic agents are available in treatment of these disorders, long-term usage has been reported to potentially...

Open access Research Article 10.9734/ajbgmb/2022/v10i230239

The Role of GTF2H1 and SULF1 Gene Polymorphisms in T2DM

Waseem Raza, Sonia Malik, Sadaf Noor, Syeda Tahira Qousain, Syed Bilal Hussain & Syed Aun Muhammad · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2022

Genetic variations could be involved in the pathogenesis of diabetes. Type 2 diabetes (T2DM) accounts for 90% of all diabetes cases worldwide, however, the percentage is higher in the South Asian region. In this study, we observed the single nucleotide polymorphism (SNP) in GTF2H...

Open access Research Article 10.9734/ajbgmb/2022/v10i130237

Hormonal Profile Evaluation in Swiss Male Mice Administered Lambda Cyhalothin and Extracts of Some Local Spices

Adetutu Olubunmi Obulor & Eme Efioanwan Orlu · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2022

Aim: This study was aimed at evaluating the hormonal profile of Swiss male mice administered lambda cyhalothin and extracts of some local spices. Experimental Design: A completely randomized experimental design using standard methods for analysis.  Location and Duration of Study:...

Open access Research Article 10.9734/ajbgmb/2022/v10i130236

Effect of Silver Nanoparticles Synthesized from Azadirachta indica Leaves Extract on Sickle Erythrocyte Membrane Stability

Mustapha Isah & Sumayya Ahmed Ayuba · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2022

Aim: To synthesize silver nanoparticles (AgNPs) from Azadirachta indica leaf extract and determine its effect on membrane stability. Place and Duration of Study: Department of Biochemistry, Sokoto State University, Sokoto, Nigeria, between January 2021 and April 2021. Methodology...

Open access Research Article 10.9734/ajbgmb/2022/v10i130233

Evaluation of the Effects of Co-administration of Ethanol Leaves Extracts of Andrographis paniculata Leaves and Phyllanthus amarus on Albumin, Globulin and Bilirubin in Heavy Metal Treated Albino Wistar Rats

Nnamso Effiong Essien, Promise-Godsfavour Mfon Bobson, Okon E. Okon & Etiowo G. Ukpong · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2022

The effect of co-administration of ethanol leaves extracts of Andrographis paniculata and Phyllanthus amarus on albumin, globulin and bilirubin in a heavy metal treated albino Wistar rats was evaluated. Twenty-five male rats (130-170g) were assigned five groups of five animals ea...

Open access Research Article 10.9734/ajbgmb/2022/v10i130234

Phytochemical and Vitamin Composition of Cucumis metuliferus Juice

Onuabuchi Nnenna Ani & Cosmas Ezekaibeya Achikanu · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2021

The pursuit of healthy lifestyle has led to increased demand for fruits and vegetables. Fruit juice in particular, is increasingly receiving attention because of the therapeutic benefits derived from its consumption. The bioactive compounds in fruit juice have various pharmacolog...

Open access Research Article 10.9734/ajbgmb/2021/v9i430232

Effects of Temperature on the Activity of Congregibacter litoralis KT 71 β -lactamase in the Hydrolysis of 4-nitrophenyl Dodecanoate

O. M. Iniaghe & R. E. Aghughu · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2021

The effects of temperature on the activities of Congregibacter litoralis KT71 β-lactamase (CLL) was determined by varying the assay temperature from 30°C to 70°C. The enzyme’s residual activity was also determined by incubating the assay mixture which excluded the substrate for o...

Open access Research Article 10.9734/ajbgmb/2021/v9i430231

Anti-Inflammatory and Analgesic Evaluation of Parinari curatellifolia Methanol Leaf Extract on Albino Rats

I. M. Fakai, A. Abdulhamid & Alhassan Yunusa Dada · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2021

Aim: This research was designed to evaluate the anti-inflammatory and analgesic activities of Parinari curatellifolia methanol leaf extract in albino rats. Methodology: Phytochemical screening was carried out using standard methods. Anti-inflammatory activity of the extract was d...

Open access Research Article 10.9734/ajbgmb/2021/v10i130229

Genetic Distance of Four Strains of Guppy Fish (Poecilia reticulata) Using RAPD PCR Method

Ayi Yustiati, Aisyah Nuryanti, Ibnu Bangkit Bioshina Suryadi & Yuniar Mulyani · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2021

Guppies are one type of organism that can live well, especially in the tropics. The kinship between species that have genetic similarities can be identified through genotypic mapping, one of which is molecular analysis using. RAPD method with PCR technique. This study aims to det...

Open access Research Article 10.9734/ajbgmb/2021/v10i130228