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A Computational Modeling Study on the Biomolecular Interactions of the Phytoconstituents of Nigella sativa with Anti-Apoptotic Proteins Mcl-1 and Bcl-x1

Olajumoke B. Oladapo, Toheeb A. Jumah, Justine U. Egbe, Jude O. Uzoechina, Aderonke E. Fakayode, Muhammad I. Adeyemi, Oluwaseyi P. Olaniyan, Chimunda A. Solomon, Zion O. Oluwasegun, Damilola M. Olatunde, Uche O. Arunsi, Samuel O. Olubode, Precious A. Akinnusi, Toheeb A Balogun & Sunday B. Akinde · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2024

Cancer is the second leading cause of mortality worldwide. The strictly controlled physiological process of apoptosis is required for immune system function, maintenance of tissue homeostasis, and appropriate embryonic development. Anti-apoptotic proteins such as Bcl-xL and Mcl-1...

Open access Research Article 10.9734/ajbgmb/2024/v16i7389

Pattern and Dynamics of Genetic Stock of Freshwater Fishes Using Various Molecular Markers for Their Conservation Management Concerns in the Indian Riverine System

Gayatri Batham & R.K. Garg · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2024

India has a world's richest, most abundant and most promising inland fisheries resources with variety fishes in tributaries, streams, canals, lakes, ponds, and reservoirs. There are several significant river systems in India, including the Cauvery, Tapi, Narmada, Krishna, Indus,...

Open access Research Article 10.9734/ajbgmb/2024/v16i7388

Phytochemical Screening, Antimicrobial and In-vitro Cytotoxic Activities of Several Extracts of Six Medicinal Plants (Crossopteryx febrifuga Benth, Khaya anthotheca, Gardenia ternifolia, and Terminalia glaucescens) from Central Africa Region

Dahirou Amadou, Hatice Korkmaz Güvenmez, Bertan Yilmaz & Sultan Girey · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2024

The qualitative study of secondary metabolites of the root and stem bark of Crossopteryx febrifuga Benth, Khaya anthotheca, Gardenia ternifolia, and Terminalia glaucescens obtained by maceration were estimated by tub reaction. Antimicrobial and cytotoxic activities of the root an...

Open access Research Article 10.9734/ajbgmb/2024/v16i7387

Effect of Ethanol Leaf Extract of Lantana camara on Fasting Blood Glucose, Body Weight and Kidney Function Indices of Alloxan-Induced Diabetic Albino Wistar Rats

Promise-Godsfavour Mfon Bobson, Elijah Udo Afangideh, Okon Effiong Okon, Mercy Okon Akpan, Ekaete Joseph Tom & Rosemary Francis Usen · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2024

The study was aimed at investigating the effect of ethanol leaf extract of Lantana camara on the fasting blood glucose, body weight and kidney function indices of alloxan-induced diabetic albino Wistar rats. Thirty male albino Wistar rats of weight 100-181 g were randomly assigne...

Open access Research Article 10.9734/ajbgmb/2024/v16i6386

Evaluation of Iodine and Goitrogens in Selected Vegetables from Owerri Imo State in Nigeria

George Chukwuemeka Nwokocha · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2024

The prevalence of iodine deficiency disorders remains a challenge in numerous developing nations despite widespread advocacy for iodized salt and iodine-fortified foods. As a result, this study assesses the iodine content of ten selected vegetables—water leaf, okra, green, tomato...

Open access Research Article 10.9734/ajbgmb/2024/v16i6385

Studies on Various Taxonomic, Pharmacognostic and Phytochemical Properties of Sanchezia speciosa Leonard Acanthaceae

Romanus A. Umoh, Imoh I. Johnny, Emmanuel R. Idio, Nsima A. Andy, Goodnews E. Charles, Anwanabasi E. Udoh, Daniel A. Owineng & TiyoAbasi A. Udom · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2024

Sanchezia speciosa Leonard, Acanthaceae is used as ornamental plant. It used in folklore medicine in the management of pain, anti-microbial and insecticide. An investigation was carried out to evaluate the various taxonomic, pharmacognostic and phytochemical standards to ensure t...

Open access Research Article 10.9734/ajbgmb/2024/v16i6384

Potential Effect of Chloroquine in Modulating Hyperglycemia and PTEN Receptor Linked Dyslipidemia on Alloxan-induced Diabetic Mice

Imaobong C. Etti, Eno-obong A. Essang & Emmanuel O. Olorunsola · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2024

Background: Diabetes mellitus is a life-threatening disease associated with worsening of glycemic control, progressive metabolic dysfunctions and disruption of the Phosphatase and Tensin Homolog (PTEN) receptor.  Purpose: To evaluate the effect of chloroquine on blood glucose lev...

Open access Research Article 10.9734/ajbgmb/2024/v16i6383

Isolation, Characterization, and Degradation Efficiency Testing of a Paclobutrazol-degrading Bacterium: Deinococcus arenae

Huang Qiuyu, Chen Juanjuan, Yao Mi, Zhang Lingna, Li Wen & Huang Yi · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2024

Objective: This study aimed to isolate and characterize a bacterium capable of degrading the pesticide paclobutrazol. The strain was obtained from soil enriched with paclobutrazol, and its degradation ability was assessed using gas chromatography (GC). Methods: A single strain wa...

Open access Research Article 10.9734/ajbgmb/2024/v16i6382

Health Risk Assessment of Organochlorine Pesticide Residues in Selected Herbal Medicines Sold in Lagos State, Nigeria

Oye Ranti Ajoke · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2024

The use of herbal medicines has a very long history for therapeutic purposes. However, cases of toxicological effects have been reported. The present study aims to assess the safety level of herbal medicines by monitoring the organochlorine pesticide (OCP) residues content. This...

Open access Research Article 10.9734/ajbgmb/2024/v16i6381

Histopathological Evaluation of the Effects of Siam Weed in Cadmium Induced Toxicity on the Liver of Wistar Rat

E,U. Eric, Avor G M & Amanukpo. P · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2024

Siam plant (Chromolaena odorata) is a plant with a characteristic aromatic smell, since ancient times, had been of interest for medical purposes in the local parlance and had been reported to be used in tradition medicine as antispasmodic, antiprotozoal, anti trypanosomal, antiba...

Open access Research Article 10.9734/ajbgmb/2024/v16i6380

Biological, Serological and Molecular Characterization of Cucumber mosaic virus (CMV) Infecting Cucurbita moschata (Duchene ex. Poir) (Summer Squash) in Itu and Uyo Local Governments Areas, Akwa Ibom State, Nigeria

Daniel A. Usanga, Ayodeji T. Owolabi & Oduba I. Eyong · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2024

Cucurbita moschata is an edible member of the family Cucurbitaceae. The plant is commonly observed showing typical virus-like symptoms during the growing season in Akwa Ibom State, Nigeria. A total of 7 leaf samples showing typical virus-like symptoms were collected from C. mosch...

Open access Research Article 10.9734/ajbgmb/2024/v16i6379

Effect of Aqueous Extract of Irvingia wombolu Seeds on Lipid Profile and Atherogenic Indices in Hyperlipidemic Wistar Rats

Joy O. Uba & Ogechukwu E. Ezim · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2024

The effect of aqueous extract of Irvingia wombolu seeds on lipid profile and atherogenic indices in hyperlipidemic wistar rats was evaluated. Forty five (45) wistar rats were grouped into five groups of nine rats each. The animals were allowed seven days acclimatization period. G...

Open access Research Article 10.9734/ajbgmb/2024/v16i6378

Adaptation and Growth Performance of Tea Plants (Camelia sinensis (L) O. Kuntze) in Obudu Hills, Cross River State

Idu, J. I., Edu, N. E., Egbaji, C. I. & Nsude, L. · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2024

Young seedlings of five tea clones under cultivation (318, 236, 68, BB35, and 143) and five from the germplasm), were collected from the Kakara Highland tea Plantations, Mambila Plateau, Taraba State. Seedlings were planted in fifty sample boxes to enable the seedlings to be esta...

Open access Research Article 10.9734/ajbgmb/2024/v16i6377

Neutrophil-lymphocyte and Platelet-lymphocyte Ratios of Pregnant Women Living with HIV/AIDS

Lebechukwu, B.C., Mbachu, N.A., Eleje, G.U., Orji, E. C., Obiegbu, N.P. & Umennadi, R.O · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2024

Background: Chronic inflammation, a factor for high mortality, persists throughout the pregnancy period of women living with human immunodeficiency Virus (HIV). Aim: To determine whether pregnancy alone or the combined effects of HIV and pregnancy are the sources of the inflammat...

Open access Research Article 10.9734/ajbgmb/2024/v16i5376

Genotoxicity and Cytotoxicity Activities of Stembark Extract of Mammea africana

Jude E. Okokon, Elvis Edet, Uchechukwu Loveth Iyanyi, Nwakaego O. Ebong, Martin Osita Anagboso & Imoh Imeh Johhny · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2024

Mammea africana, a medicinal plant, used in ethnomedicine for the treatment of malaria, diabetes, poisoning and inflammatory diseases was investigated for cytotoxic and genotoxic effects on the root meristem cells of Allium cepa. Onion bulbs were exposed to 2.5 mg/mL, 5mg/mL, and...

Open access Research Article 10.9734/ajbgmb/2024/v16i5374