Aim: This study was to investigate the effect of dietary lemon peel extract (LPE) on high fat diet induced obesity in rats. Some of the LPE mechanism of action was also elucidated. Fifty adult rats were divided into five groups: 1) normal control, 2) lemon peel extract group supp...
Open access
Research Article10.9734/IJBCRR/2016/26651
Aim: To determine the in-vivo antiplasmodial activity of aqueous, N-butanol and ethylacetate fractions of leaf and stem bark methanol extracts of Diospyros mespiliformis on Plasmodium berghei berghei (Nk65) infected mice. Place and Duration of Study Sample: Biochemistry Departmen...
Open access
Research Article10.9734/IJBCRR/2016/21645
The safety of monosodium glutamate (MSG) usage has generated much controversy, because of the toxic nature of monosodium glutamate which is often added to food to improve taste and the fear that this may have deleterious effect on many organs of the body is on the increase. The e...
Open access
Research Article10.9734/IJBCRR/2016/26324
Aim: This study was designed to assess the effects of different doses of atorvastatin on fasting blood sugar, body weight, haematological indices, serum calcium and CRP levels in female albino wistar rats. Study Design: Twenty-four female albino wistar rats weighing 125 to 150 g...
Open access
Research Article10.9734/IJBCRR/2016/26548
Aims: The aim of this study is to investigate the protective effect of sulphasalazine on liver fibrosis. Besides; investigation of the expression pattern of transforming growth factor β receptor I (TGFβRI) in liver fibrosis and the possible modulatory effect of sulphasalazine on...
Open access
Research Article10.9734/IJBCRR/2016/25627
Aim: The aim of our study was to assess the utility of lipoprotein (a) as a reliable cardiovascular risk marker in hypothyroid patients. This involved estimation and comparison of lipoprotein (a) levels between hypothyroid patients and healthy adults. To correlate lipoprotein (a)...
Open access
Research Article10.9734/IJBCRR/2016/26843
Aim: The study determined prevalence of clinically relevant CYP2C8*5 polymorphism in 80 unrelated individuals, from selected ethnic groups in Southern Ghana. Medical history on adverse drug reactions of the subjects and level of dependency on drugs metabolized by CYP2C8 enzyme wa...
Open access
Research Article10.9734/IJBCRR/2016/25680
Aims: The aim of this study is to investigate the expression pattern of transforming growth factor β receptor I(TGFβRI) and fibroblast growth factor receptor 3 (FGFR3) at the different stages of liver injury including acute injury, fibrosis and cirrhosis. Study Design: Controlled...
Open access
Research Article10.9734/IJBCRR/2016/26031
The manganese, Zinc and chloride content in milk of West African dwarf (WAD) goats as influenced by stage of lactation was assessed using three WAD does aged 18 months of age, weighing from 19 to 20 Kg. They were kept for lactation studies lasting for two 10-weeks periods. Indivi...
Open access
Research Article10.9734/IJBCRR/2016/25927
Objective: The effect of ethanol leaf extract of A. wilkesiana on the liver of paracetamol- induced hepatotoxicity was investigated in wistar albino rats. Study Design: Animal experimental study. Place of Study: Department of Biochemistry, Faculty of Biological science University...
Open access
Research Article10.9734/IJBCRR/2016/25588
The aim of the study was to investigate the chelation potential of aqueous leaf extracts of Vernonia amygdalina and Phyllanthus amarus in albino wistar rats intoxicated with lead using kidney function markers as indicators, and compare results to an EDTA chelation therapy. Both p...
Open access
Research Article10.9734/IJBCRR/2016/25356
Aims: To elucidate the pathogenicity of Aspergillus nidulans, elastolytic protease was isolated from the culture supernatant of the isolate, and its biological activity and cytotoxicity were examined. Methodology: A. nidulans (NBRC 4340) spores were cultured on YCB-elastin medium...
Open access
Research Article10.9734/IJBCRR/2016/26206
Aims: The aim of this study is to explore the expression pattern of LIGHT and FGF-BP at the different stages of liver injury including acute injury, fibrosis and cirrhosis. Study Design: Controlled experiment. Place and Duration of Study: Department of Biochemistry and Departmen...
Open access
Research Article10.9734/IJBCRR/2016/26029
Increase in prevalence of resistant microorganisms especially to synthetic drugs, has necessitated the need to search for new bioactive compounds having natural origin. Thus it was essential to determine the antibacterial activity of hexane, dichloromethane, ethyl acetate and met...
Open access
Research Article10.9734/IJBCRR/2016/25863
Aims: The present study demonstrated a comparative evaluation of RNA isolation from pigeonpea by using conventional or modified laboratory based methods as well as optimizing the existing well known protocol to extract a satisfactory amount of purified and reproducible RNA requir...
Open access
Research Article10.9734/IJBCRR/2016/25978