Background: Refractory ascites is a major complication of cirrhosis with a 1-year survival rate of less than 50%. Large-volume paracentesis (LVP) is the standard treatment but does not improve survival and carries risks of circulatory dysfunction. Midodrine, an oral alpha-adrener...
Open access
Research Article10.9734/irjgh/2026/v9i1146
Lead acetate exposure induces oxidative stress and pancreatic damage, representing a critical public health concern. Brassica oleracea is recognized for its antioxidant and protective bioactivities, but its efficacy against lead-induced pancreatic toxicity requires further evalua...
Open access
Research Article10.9734/irjgh/2026/v9i1145
Introduction: Conventional management of early gastric cancer (EGC) includes standard anatomical gastrectomy along with D1/D2 lymph node dissection. Despite achieving oncological excellence, this approach affects patients' quality of life. Few approaches have been developed to co...
Open access
Research Article10.9734/irjgh/2026/v9i1144
Drug-induced gastritis (DIG) represents an underrecognized yet clinically important cause of gastric mucosal injury with significant morbidity and mortality. It arises from the widespread use of medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, b...
Open access
Research Article10.9734/irjgh/2026/v9i1143
Background: Hepatitis B virus (HBV) infection remains a significant global health problem, particularly in sub-Saharan Africa, where it contributes substantially to maternal and neonatal morbidity. There is an increased risk of vertical transmission and other adverse events from...
Open access
Research Article10.9734/irjgh/2026/v9i1142
Background: Hepatitis C virus (HCV) infection is a significant public health challenge in Nigeria, contributing heavily to chronic liver disease, including cirrhosis and hepatocellular carcinoma. While recent data is emerging, national estimates indicate a varied, often underrepo...
Open access
Research Article10.9734/irjgh/2026/v9i1141
Tramadol, a synthetic opioid analgesic, is frequently misused for non-medical purposes, resulting in several adverse effects, including pancreatic toxicity. The pancreas, due to its dual exocrine and endocrine functions, is highly vulnerable to drug-induced oxidative stress and i...
Open access
Research Article10.9734/irjgh/2026/v9i1140
Background: Obesity is a chronic condition described as excessive fat accumulation, which has the potential to severely impact one’s health. It develops through a combination of several factors such as genetics, metabolic conditions, diet, physical activity and much more. The rat...
Open access
Research Article10.9734/irjgh/2026/v9i1139
Background: Diarrheal diseases continue to constitute challenges to public health globally, with children under five years in underdeveloped and developing countries being the most affected. Aim: The current study aimed to determine the pathogenic bacterial and protozoan agents a...
Open access
Research Article10.9734/irjgh/2026/v9i1138
Background: Obesity is a major public health challenge associated with numerous chronic conditions, including diabetes, polycystic ovarian syndrome(PCOS), hypertension, stroke, gastroesophageal reflux disease( GERD), metabolic dysfunction-associated steatotic liver disease (MASLD...
Open access
Research Article10.9734/irjgh/2026/v9i1137
Background: Helicobacter pylori (H. pylori) infection is a major public health concern and is strongly associated with various gastrointestinal (GI) disorders, including gastritis, peptic ulcer disease, and gastric cancer. Aim: This study aimed to determine the prevalence of H. p...
Open access
Research Article10.9734/irjgh/2026/v9i1136
Background: Gastrointestinal (GIT) bleeding in children is a common but potentially serious condition with diverse etiologies that vary between regions. Endoscopy remains the cornerstone for diagnosis and management. This study evaluates the epidemiological characteristics, etiol...
Open access
Research Article10.9734/irjgh/2025/v8i1135
Background: Helicobacter pylori is one of the most common bacterial infections worldwide, affecting up to 75% of the population, and is a major cause of upper gastrointestinal diseases, including gastric cancer. Effective eradication is crucial to prevent disease progression and...
Open access
Research Article10.9734/irjgh/2025/v8i1134
McHenry Stephen, Obed Joy Mesan, Kumbugu Dan-Barry Ashlameh, China Wolbe, Oguchukwku Harry Ifeacho, Augustine Enenche, Bello Adabe, Duguru Mary, Felix Agnes Uduh, Abdulrahaman Adelodun Lukman, Okpe Mathew, Udeh Eberechukwu Njideka, Job Luvo Alphia, Yahaya Baba Adamu, Okeke Edith & Malu A.O·International Research Journal of Gastroenterology and Hepatology·2025
Background: Helicobacter pylori is seroprevalent globally (about half of the world). It’s a cause of both gastric and extra-gastric conditions. Nigeria has one of the highest prevalences in the world. Demonstrating the presence of an active organism is very important, as not all...
Open access
Research Article10.9734/irjgh/2025/v8i1133
Background: Ursodeoxycholic acid (UDCA), a hydrophilic bile acid, has established therapeutic benefits in several liver disorders. It is the first-line treatment for primary biliary cholangitis (PBC), where it improves liver enzyme levels, slows disease progression, and enhances...
Open access
Research Article10.9734/irjgh/2025/v8i1132