Background: Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are major causes of chronic liver disease and are associated with complex host immune and inflammatory responses. Interleukin-6 (IL-6) is an important pro-inflammatory cytokine involved in immune regulatio...
Open access
Research Article10.9734/irjgh/2026/v9i1160
Background: Non-linear models, unequal (random) estimation uncertainty, repeated observations, and temporal autocorrelation are not adequately addressed in conventional liver-burden studies, which typically use percentage changes or linear annual trends. The purpose of this study...
Open access
Research Article10.9734/irjgh/2026/v9i1161
Aim: To investigate the time-dependent effects of activated charcoal on cytochrome P450 (CYP2E1) activity, oxidative stress (SOD), liver injury enzymes (AST, ALT, ALP, and GGT), and hepatic function parameters (total protein, albumin, and total bilirubin) in albino rats exposed t...
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Research Article10.9734/irjgh/2026/v9i1159
Non-cirrhotic portal hypertension is an uncommon cause of variceal bleeding and requires careful evaluation for vascular, hepatic, infectious, autoimmune, metabolic, and haematological causes. Chronic myelomonocytic leukaemia is a clonal haematological malignancy characterised by...
Open access
Research Article10.9734/irjgh/2026/v9i1158
Leptospirosis is a bacterial zoonosis that may rarely cause severe hepatic involvement and fulminant acute liver failure. We report a 32-year-old man with no notable medical history who presented after seven days of fever, intense myalgia, headache, and vomiting, with recent expo...
Open access
Research Article10.9734/irjgh/2026/v9i1157
Wernicke encephalopathy is an acute neurological disorder caused by thiamine deficiency and is often under-recognised in patients without chronic alcohol misuse. Prolonged vomiting and impaired nutritional intake may rapidly deplete thiamine stores and precipitate neurological de...
Open access
Research Article10.9734/irjgh/2026/v9i1155
Ibrahim Hussain Alzahib, Ensaf Adnan Mousa AlBokhari, Khalid Hazim A. Alotaibi, Mashael Zayed M. AlBalawi, Bader Abdulrahman Husayyan Alanazi, Metab Ali Saeed Alasmari, Mohammed Hussain Abdulrahman Alzahib & Norah Saad Jubran Alkahtani·International Research Journal of Gastroenterology and Hepatology·2026
Background: Metabolic dysfunction-associated steatohepatitis (MASH), formerly termed nonalcoholic steatohepatitis, can progress to advanced fibrosis, cirrhosis, hepatic decompensation, hepatocellular carcinoma, transplantation, and death. Resmetirom and semaglutide have reached c...
Open access
Research Article10.9734/irjgh/2026/v9i1156
Background: Alcoholic hepatitis (AH) is a serious medical condition with limited treatment options and significant short-term mortality risk. While S‑adenosyl methionine (SAMe) and ursodeoxycholic acid (UDCA) individually exhibit hepatoprotective properties, their combination rem...
Open access
Research Article10.9734/irjgh/2026/v9i1154
Aims: Capsule endoscopy (CE) has become an essential diagnostic tool for small-bowel evaluation. Despite its high diagnostic yield and safety profile, technical limitations and clinical complications may affect its performance. This study aimed to evaluate the diagnostic performa...
Open access
Research Article10.9734/irjgh/2026/v9i1153
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis frequently associated with inflammatory bowel disease (IBD), particularly ulcerative colitis (UC). Although PG usually occurs during established IBD, it may rarely precede intestinal manifestations, creating a significan...
Open access
Research Article10.9734/irjgh/2026/v9i1152
Behçet’s disease is a rare systemic vasculitis that can affect the gastrointestinal tract. Intestinal involvement, or enteric Behçet’s disease, can mimic Crohn’s disease, making the differential diagnosis complex, particularly in chronic and fistulizing forms. We report the case...
Open access
Research Article10.9734/irjgh/2026/v9i1151
Hepatic echinococcosis is an endemic parasitic disease in several regions of the world, particularly the Mediterranean basin. A hydatid cyst of the liver is usually a benign condition, but it can lead to rare complications, including portal hypertension due to an intrahepatic obs...
Open access
Research Article10.9734/irjgh/2026/v9i1150
Background: Type 2 diabetes mellitus (T2DM) poses a significant public health challenge in Nigeria, exacerbated by the psychosocial burden of the disease. While nurse-led education is a promising intervention, evidence regarding its impact on coping strategies and health-related...
Open access
Research Article10.9734/irjgh/2026/v9i1149
Introduction: Globally, the occurrence of gastrointestinal diseases appears to have increased rapidly and currently accounts for the upsurge in disease burden and household expenditures on healthcare. For example, a 25.82 percent increase in the occurrence of gastric ulcers was r...
Open access
Research Article10.9734/irjgh/2026/v9i1148
Background: Helicobacter pylori infection remains a major global public health concern, with disproportionately high prevalence in developing countries such as Nigeria. Aims: This study presents a narrative review of the epidemiology, transmission dynamics, risk factors, diagnost...
Open access
Research Article10.9734/irjgh/2026/v9i1147