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Induction Chemotherapy as a Predictor for Definitive Treatment in Bulky Locally Advanced Squamous Cell Carcinoma of the Head and Neck: A Schedule More Suited to Sub Himalayan Region

Vipul Nautiyal, Saurabh Bansal, Manisa Pattanayak, Deep S. Pruthi, Mushtaq Ahmad & Sunil Saini · Journal of Cancer and Tumor International · 2017

Purpose: Use of induction chemotherapy (IC) as a predictor for definitive treatment in bulky locally advanced head and neck cancer (LA HNSCC) patients, who are not feasible for any upfront radical treatment in sub-Himalayan population. Materials and Methods: 33 patients (stage IV...

Open access Research Article 10.9734/JCTI/2017/38073

Nutritional Status of Lung Cancer Patients in Benghazi City of Libya

Faiza Nouh, Mariam Omar, Manal Younis, Moftah Younis, Rasha Mohamed, Ra'eka Gaith & Weaam Reyad · Journal of Cancer and Tumor International · 2017

Lung cancer is one of the most common type of cancer in the world and Libya is no exception. Nutrition intervention is often needed for nutrition-related complications of cancer treatment, which include but are not limited to vomiting, anorexia, nausea and, and esophagitis. The p...

Open access Research Article 10.9734/JCTI/2017/38345

Epidemiomorphology of Prostate Cancer in Cameroon: About 1047 Cases

Jean Paul Ndamba Engbang, Beyeme Sala, Herve Moby, Yoan Ligan, Bruno Djougmo Djimeli, Godefroy Simo, André Moune, Albert Sone Mouelle, Amadou Fewou, Jean Louis Oyono Essame & Alan Hasigov · Journal of Cancer and Tumor International · 2017

Objective: To determine the epidemiological and histological profile of prostate cancer in Cameroon. Materials and Methods: It was a descriptive and retrospective study over a period of 12 years (2004-2015), concerning prostate cancers in five regions (Center, Littoral, West, Nor...

Open access Research Article 10.9734/JCTI/2017/37565

ABL1 is Overexpressed and Activated in Hepatocellular Carcinoma

Lennox Chitsike, Xianzhong Ding, Peter Breslin & Wei Qiu · Journal of Cancer and Tumor International · 2017

Background and Aims: ABL1 is a non-receptor tyrosine kinase of the Abelson (Abl) family, which plays an important role in cell growth, survival, invasiveness, adhesion, and migration. Despite the well-known role of BCR-ABL in hematologic malignancies, the role of ABL1 in hepatoca...

Open access Research Article 10.9734/JCTI/2017/37131

Effect of Ethanol Extract of Abrus precatorious Seed on Testosterone-Induced Benign Prostatic Hyperplasia in Adult Male Wistar Rats

I. I. Bello, O. T. Kunle-Alabi, T. F. Abraham & Y. Raji · Journal of Cancer and Tumor International · 2017

Aim: To assess the effects of Abrus precatorious seed extract on prostate weight and hormonal levels (dihydrotestosterone, testosterone and estrogen) of male Wistarrats. Study Design: The study was divided into six groups A, B, C, D, E and F. Place and Duration of Study: The stud...

Open access Research Article 10.9734/JCTI/2017/34832

Analysis of Orthopedic Surgery for Long Bone Metastases and Pathologic Fractures

A. I. Radchenko, A. G. Zhukovets & Y. M. Bogdayev · Journal of Cancer and Tumor International · 2017

The study made a retrospective analysis of treatment outcomes in 105 patients subjected to 128 surgical interventions for metastatic involvement of long tubular bones. Endoprosthetic replacement of large joints (40.2%) and intramedullary osteosynthesis (29.7%) were the main types...

Open access Research Article 10.9734/JCTI/2017/36830

Pediatric and Adolescent Malignant Ovarian Tumors: Mansoura 5 - Year Experience

Mohamed Sarhan, Amal Halim, Ibrahim Elzayat, Tamer Saber, Amira El-Hawary, Adel El-Badrawy, Hanan Wahba, Hend El-Hadaad, Omar Farouk & Wagdi El Kashif · Journal of Cancer and Tumor International · 2017

Background: Pediatric ovarian tumors are rare. The aim of this work is to study the epidemiological characteristics and treatment outcome of these tumors in our locality. Methods: This retrospective study was performed in accordance with the ethical policies. Between January 2011...

Open access Research Article 10.9734/JCTI/2017/36261

No Evidence for Association of -2518 A/G Promoter Polymorphism of MCP-1 with Risk of Esophageal Cancer in Punjab, North-West India

Vasudha Sambyal, Kamlesh Guleria, Mridu Manjari, Meena Sudan, Manjit Singh Uppal & Neeti Rajan Singh · Journal of Cancer and Tumor International · 2017

Aim: To investigate the role of MCP-1 -2518 A/G polymorphism in the susceptibility to esophageal cancer in patients from Punjab, North-West India. Methods: In this case-control study, 159 sporadic esophageal cancer patients and 159 age and gender matched controls were included. M...

Open access Research Article 10.9734/JCTI/2017/36431

Impact of ADAM17 Expression as a Potential Prognostic Biomarker and Target for Therapy in Node-negative Breast Carcinoma

Regina Sam, Carlos Lopes, Oriana Marques, Claudia Carvalho & Samuel Victor Nuvor · Journal of Cancer and Tumor International · 2017

Aims: To evaluate the expression and the possible prognostic impact of the tissue-based protein ADAM17 in node-negative breast cancer and investigate its association with clinical and pathological features to aid in differentiating indolent node-negative breast cancer from aggres...

Open access Research Article 10.9734/JCTI/2017/35955

Occurrence of Factors Influencing Recurrence and/or Metastasis in Dermatofibrosarcoma Protuberans

A. Y. Benneh, P. S. Kay, M. J. Hale, J. B. L. Kiluba & T. E. Luvhengo · Journal of Cancer and Tumor International · 2017

Introduction: Dermatofibrosarcoma protuberans (DFSP) is a slow growing tumour with limited metastatic potential. However it acquires aggressive attributes as it enlarges or if it recurs following excision. The fibrosarcomatous (FS) variant of DFSP has a higher propensity for loca...

Open access Research Article 10.9734/JCTI/2017/35247

Can Calcium and Magnesium Infusion before and after Oxaliplatin Administration Improves Its Neurotoxic Effect?

Mohamed S. Zahi & Hend M. Hamdey Rashed Elkalla · Journal of Cancer and Tumor International · 2017

Introduction: The oxaliplatin neurotoxicity is one of two distinct phases: an acute and a dose-limiting cumulative phase. Large doses of I.V Ca & Mg is given before and after oxaliplatin in FOLFOX protocol. Aim: We aimed to evaluate the efficacy of Ca & Mg in improving or...

Open access Research Article 10.9734/JCTI/2017/35988

Do pathologists thoroughly Evaluate the Greater Omentum Following Gastrectomy for Malignancy: an Audit Based on Histopathology Reports

O. Tobiko, J. Kiluba, C. Jann-Kruger, M. J. Hale & T. E. Luvhengo · Journal of Cancer and Tumor International · 2017

Introduction: Milky spots in greater omentum are primary sites for seeding of exfoliated cells from intra-abdominal malignancies. Surgery is the mainstay of treatment of gastric adenocarcinoma and the greater omentum is usually resected en-bloc.   Aim: To study the histopathologi...

Open access Research Article 10.9734/JCTI/2017/35246

Evaluation of Efficacy of Gefinitib in Comparison with Chemotherapy in Patients with Non-Small Cell Lung Carcinoma from India

Shyam Aggarwal, Sachin Minhas, Mayank Jauhri, Yogender Shokeen, Madhusudan Ganvir, Manish Pungliya, C. T. Sateesh, H. P. Shashidhara & Shekar Patil · Journal of Cancer and Tumor International · 2017

Aim: Tyrosine kinase inhibitors (TKIs) are a new class of drugs that are proven to be more efficacious than chemotherapy in certain cancers including lung cancer. However, the efficacy of TKIs may vary in different global populations as different ethnic populations have different...

Open access Research Article 10.9734/JCTI/2017/35710

A Rare Case Report of a Metastatic Tumor of the Spermatic Cord Arising from Pancreatic Cancer

Ryuta Sato, Dai Watanabe, Masaharu Imagawa, Masahiro Okamoto, Kengo Fukuzawa & Hirotoshi Yonemasu · Journal of Cancer and Tumor International · 2017

A 60-year-old patient complaining of pain and elevation of the right scrotal contents, who had been treated for pancreatic cancer, was suspected of having spermatic cord tumor. He underwent high orchiectomy for pain management and pathological diagnosis. The tumor was a metastati...

Open access Research Article 10.9734/JCTI/2017/35465

Symptoms Burden, Quality of Life and Its Determinant Factors in Advanced Lung Cancer Patients

Asma Ammar, Mariem Dhahri, Iheb Bougmiza, Rim Chafai, Faten Ezzairi, Mansour Njah & Nabiha Bouafia · Journal of Cancer and Tumor International · 2017

Aims: To assess in advanced lung cancer patients’, reported symptoms burden, their QOL, and to identify determinant factors associated with their QOL in 2 healthcare departments. Study Design: A cross sectional study. Place and Duration of the Study: The study was carried out dur...

Open access Research Article 10.9734/JCTI/2017/35636