Skip to content
Research Article Open access CC BY 4.0

Pediatric and Adolescent Malignant Ovarian Tumors: Mansoura 5 - Year Experience

Mohamed Sarhan, Amal Halim, Ibrahim Elzayat, Tamer Saber, Amira El-Hawary, Adel El-Badrawy, Hanan Wahba, Hend El-Hadaad, Omar Farouk, Wagdi El Kashif

Journal of Cancer and Tumor International · pp. 1–10 · Published 13 Oct 2017

10.9734/JCTI/2017/36261

Abstract

Background: Pediatric ovarian tumors are rare. The aim of this work is to study the epidemiological characteristics and treatment outcome of these tumors in our locality. Methods: This retrospective study was performed in accordance with the ethical policies. Between January 2011 to December 2015, Thirteen cases of pediatric ovarian cancers were recorded in the Pediatric Oncology Unit of Oncology Center of Mansoura University and the Clinical Oncology & Nuclear Medicine Department of Mansoura University Hospital. The clinico-epidemiologic data and the treatment protocols were analyzed.  Results: The median age was 10 years (range: 2-17). Presenting symptoms were mainly lower abdominal pain (6; 46.2%) and palpable abdominal mass (4; 30.7). Through laparotomy all patients underwent unilateral salpingo-oophorectomy except one case for whom bilateral salpingio-oophorectomy was done. Six patients were stage I (46.2%), 2 patients were stage II (15.4%) and 5 patients were stage III tumors (38.4%). The majority had germ cell tumors (11; 85%). Adjuvant chemotherapy was given to all cases. Further chemotherapy was needed in 6 cases due to progression or recurrence. The median follow up was 35 months while the median overall survival was 40 months. Mortality rates were 90% in stages II and III together. The advanced stages and yolk sac pathology had the highest mortality. One of the survived cases got married and delivered a baby. Conclusion: Germ cell tumors are the commonest pediatric malignant ovarian tumors. Multimodality treatment is essential. Fertility preservation should be respected. Our mortality rates are relatively high.  

Pediatric ovarian tumors germ cell tumors PEB protocol JEB

References (27)

  1. 1 Management of Ovarian Germ Cell Tumors [DOI]
  2. 2 The role of staging and adjuvant chemotherapy in stage I malignant ovarian germ cell tumors (MOGTs): the MITO-9 study [DOI]
  3. 3 Outcomes of pediatric and adolescent girls with malignant ovarian germ cell tumors [DOI]
  4. 4 Prognostic Factors in Children With Localized Malignant Nonseminomatous Germ Cell Tumors [DOI]
  5. 5 Neo-adjuvant chemotherapy in the treatment of advanced malignant germ cell tumors of ovary [DOI]
  6. 6 Sex-Cord Stromal Tumors in Children and Teenagers: Results of the TGM-95 Study [DOI]
  7. 7 Current Strategy for the Treatment of Ovarian Germ Cell Tumors: Role of Extensive Surgery [DOI]
  8. 8 Use of laparoscopic surgical resection for pediatric malignant solid tumors: a case series [DOI]
  9. 9 Management of Bilateral Malignant Ovarian Germ Cell Tumors [DOI]
  10. 10 Ovarian tumors during childhood and adolescence. A clinicopathological study.
  11. 11 A Huge Ovarian Mucinous Cystadenoma in a 14-Year-Old Premenarchal Girl: Review on Ovarian Mucinous Tumor in Premenarchal Girls [DOI]
  12. 12 Surgery for germ cell tumors [DOI]
  13. 13 Mucinous cystadenoma of the ovary in a 12-year-old girl [DOI]
  14. 14 Ovarian tumors in pediatric age group - A clinicopathologic study of 10 years′ cases in West Bengal, India [DOI]
  15. 15 Ovarian cysts and tumors in infancy and childhood [DOI]
  16. 16 Racial disparities in survival in malignant germ cell tumors of the ovary [DOI]
  17. 17 Adolescent ovarian masses: A retrospective analysis [DOI]
  18. 18 Spectrum of Childhood and Adolescent Ovarian Tumors in India: 25 Years Experience at a Single Institution [DOI]
  19. 19 Tailored therapy and long-term surveillance of malignant germ cell tumors in the female genital system: 10-year experience [DOI]
  20. 20 Outcomes of Malignant Ovarian Germ-Cell Tumors Treated in Chiang Mai University Hospital over a Nine Year Period [DOI]
  21. 21 Ovarian Cancer in Children and Adolescents: Treatment and Reproductive Outcomes [DOI]
  22. 22 In utero exposure to female hormones and germ cell tumors in children [DOI]
  23. 23 Clinical Presentation and Outcome of Pediatric Ovarian Germ Cell Tumor: A Study of 40 Patients [DOI]
  24. 24 Oophorectomy versus salpingo-oophorectomy in Turner syndrome patients with Y-chromosome material: clinical experience and current practice patterns assessment [DOI]
  25. 25 MALIGNANT OVARIAN GERM CELL TUMORS AT A TERTIARY CARE SETTING IN PAKISTAN.
  26. 26 Management of bilateral malignant ovarian germ cell tumors: Experience of a single institute [DOI]
  27. 27 MicroRNAs and Recent Insights into Pediatric Ovarian Cancers [DOI]

Cited by 0

No indexed citations yet.

Article metrics

Real usage data collected on this platform.

20

Page views

0

PDF downloads

0

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.