The Effect of Indomethacin on the Sperm Motility of Adult Wistar Rats

Abstract

Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) used mostly in the treatment of pain, feverish condition, headaches and inflammation. This study was therefore carried out to evaluate the effect of indomethacin on the male reproductive system, focusing on sperm quality. Twenty male rats were divided into four groups, (groups1,2,3,and 4) with group one serving as control. The other three groups receiving different doses of indomethacin, (groups 2-4 receiving 1mg/kg, 2mg/kg and 4mg/kg respectively) for 21 days. After the period, sperm samples were collected from all the groups and analyzed to evaluate sperm quality. The sperm qualities analyzed include; sperm motility, semen viscosity, sperm morphology, sperm count, etc. the results of the study indicated that indomethacin had a negative impact on the sperm qualities of the rats, as it decreased sperm count and sperm motility , and had a detrimental effect on the overall sperm quality. This study provides important insights into the potential side effects of indomethacin on male fertility. While its therapeutic benefits are well established, its impact on male fertility has not been documented. The findings of this study suggest that men who use indomethacin regularly may be at a higher risk of experiencing negative impacts on their reproductive health, including reduced sperm quality.