Transferosome: A Novel Transdermal Drug Delivery System for the Treatment of Hyperlipidemia

Abstract

Hyperlipidemia describes a group of genetic along with medical conditions which raise cholesterol levels throughout the bloodstream. Many individuals suffer from this illness. It puts the patient at risk for major problems such heart disease, brain strokes, hepatic malfunction, and renal dysfunction. The barrier function of the skin usually restricts transdermal drug delivery, although it has evolved into a helpful strategy for therapeutic pharmacological compound administration. Transfersomes are ultradeformable nanovesicles made of lipid bilayer of phospholipids in conjugation with edge activator that surrounds an aqueous core. Transfersomes are mainly prepared by film hydration method, reverse-phase evaporation method, modified handshaking method, vortexing–sonication method, and ethanol injection method. By using an extremely deformable vesicular carrier to transfer bioactive chemicals through the skin more effectively, new potential and difficulties for the creation of innovative, enhanced therapeutics are presented. Since transfersomes are specifically optimized vesicles with the ability to respond to an external stress via quick and energy- efficient shape changes, it can solve all the issues with transdermal administration. Transfersomes have high entrapment efficiency and increase bioavailability. The use of transfersomes as a Transdermal delivery system for drugs with hyperlipidemia-active medication is part of an efficient treatment regimen for the hyperlipidemia disease.