An Assessment of Potential In-vivo Hepatoprotective Properties of Vitis vinifera in Experimental Rat Model

Abstract

Many civilizations have long employed herbal treatments to treat ailments. It has been shown that these medicinal plants contain a number of phytochemicals that can treat a variety of ailments, from minor to serious. A focused search for alternative natural therapeutic agents was inspired by the shortcomings of traditional medications and their peculiar adverse effects. The availability of natural products and their lack of negative side effects could be another explanation for this goal. Human healthcare has historically benefited greatly from the grape plants and the ingestion of grape fruits. Vitis vinifera is known to have astringent, demulcent, carminative, diuretic, laxative, wound-healing, stomachic characteristics. V. Vinifera are widely used to treat bronchitis, allergies, the common cold, the flu, anemia, and other conditions. The blooms are also known to have expectorant and hematinic effects. Moreover, there are broad spectrum anti-inflammatory, anti-hypertensive, antineoplastic, anti-carcinogenic, anti-fibrotic, anti-viral, anti-fungal, anti-bacterial, anti-ulcerant, anti-aging, anti-asthma, anti-obesity, hyperpigmentation, wound-healing (cicatrizing) properties as well as immunomodulatory, cardio-protective, and neuroprotective roles have been reported. The present study looked into the unexplored hepatoprotective and anti-oxidant potentialities of ethanolic fruit extract of V. vinifera against toxic chemical CCl4-induced hepatotoxicity in male Wistar rats. In the present study, the extract shows a tremendous result as a hepato-protective and an antioxidant agent considering (p*<0.05) in a dose-dependent manner. In lower doses the grape extract shows reversing physiological effects and in higher doses, it shows better therapeutic effects comparing the marketed drugs for hepatoprotective response.