Skip to content
Research Article Open access CC BY 4.0

What a Clinical Hematologist should Know about B Cells?

Sanjeev Kumar Sharma

International Blood Research & Reviews · pp. 8–22 · Published 10 Jan 2022

10.9734/ibrr/2022/v13i130166

Abstract

B cells are very crucial part of our immune system. They protect us from various infections by secreting antigen-specific antibodies, which neutralize the infectious agents. It is important for a clinical hematologist to know about the B cell development, function and the diseases developing from the quantitative or qualitative defects in B cells. This simple and short review is focused on the basic understanding and clinical hematologist’s perspective of B cells.

Clinical hematologist B cells immune system stem cell transplantation

References (43)

  1. 1 WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
  2. 2 Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [DOI]
  3. 3 Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray [DOI]
  4. 4 Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme [DOI]
  5. 5 B lymphocytes: how they develop and function [DOI]
  6. 6 An introduction to immunology and immunopathology [DOI]
  7. 7 Germinal Center B Cell Dynamics [DOI]
  8. 8 Germinal-Center Organization and Cellular Dynamics [DOI]
  9. 9 Mechanisms of B-cell lymphoma pathogenesis [DOI]
  10. 10 Germinal centres: role in B-cell physiology and malignancy [DOI]
  11. 11 B-cell biology and development [DOI]
  12. 12 The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry [DOI]
  13. 13 Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation [DOI]
  14. 14 The establishment of resident memory B cells in the lung requires local antigen encounter [DOI]
  15. 15 RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia [DOI]
  16. 16 Thymus-Independent and Thymus-Dependent Responses to Polysaccharide Antigens [DOI]
  17. 17 Regulatory Mechanisms that Determine the Development and Function of Plasma Cells [DOI]
  18. 18 Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma [DOI]
  19. 19 Commitment of B Lymphocytes to a Plasma Cell Fate Is Associated with Blimp-1 Expression In Vivo [DOI]
  20. 20 Molecular Mechanisms of Somatic Hypermutation and Class Switch Recombination [DOI]
  21. 21 The Maintenance of Memory Plasma Cells [DOI]
  22. 22 A new vision of immunity: homeostasis of the superorganism [DOI]
  23. 23 High grade B-cell lymphoma with rearrangements of MYC and BCL2 and/or BCL6: Double hit and triple hit lymphomas and double expressing lymphoma [DOI]
  24. 24 Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia [DOI]
  25. 25 The oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B-cell lymphomas [DOI]
  26. 26 Guidelines for the management of diffuse large B‐cell lymphoma [DOI]
  27. 27 How I treat posttransplant lymphoproliferative disorders [DOI]
  28. 28 Background to hematopoietic cell transplantation, including post transplant immune recovery [DOI]
  29. 29 Immune reconstitution and implications for immunotherapy following haematopoietic stem cell transplantation [DOI]
  30. 30 Plasma cell differentiation during the germinal center reaction [DOI]
  31. 31 What a Clinical Hematologist Should Know about T Cells? [DOI]
  32. 32 Thymus-Marrow Cell Combinations. Synergism in Antibody Production. [DOI]
  33. 33 Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts [DOI]
  34. 34 Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts [DOI]
  35. 35 B cell reconstitution after human bone marrow transplantation: recapitulation of ontogeny?
  36. 36 Repression of BCL-6 is required for the formation of human memory B cells in vitro [DOI]
  37. 37 Characteristic Pattern of Chromosomal Imbalances in Posttransplantation Lymphoproliferative Disorders: Correlation with Histopathological Subcategories and EBV Status [DOI]
  38. 38 Principles of innate and adaptive immunity
  39. 39 Pre-B cell receptor–mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC [DOI]
  40. 40 Aggressive B-cell lymphomas—from morphology to molecular pathogenesis [DOI]
  41. 41 Antigen receptor diversification and chromosome translocations [DOI]
  42. 42 Role of the surrogate light chain and the pre‐B‐cell receptor in mouse B‐cell development [DOI]
  43. 43 Pre-B Cell Receptor-Mediated Activation of BCL6 Induces Pre-B Cell Quiescence Through Transcriptional Repression of MYC [DOI]

Cited by 22

T Cell Development

Sanjeev Kumar Sharma · Basics of Hematopoietic Stem Cell Transplant · 2023

Primary Immunodeficiency Diseases

Sanjeev Kumar Sharma · Basics of Hematopoietic Stem Cell Transplant · 2023

Basics of Stem Cell Transplant

Sanjeev Kumar Sharma · Basics of Hematopoietic Stem Cell Transplant · 2023

Stem Cell Transplant for B Cell Non-Hodgkin Lymphoma

Sanjeev Kumar Sharma · Basics of Hematopoietic Stem Cell Transplant · 2023

Vaccinations Post Stem Cell Transplant

Sanjeev Kumar Sharma · Basics of Hematopoietic Stem Cell Transplant · 2023

Chronic Graft-Versus-Host Disease

Sanjeev Kumar Sharma · Basics of Hematopoietic Stem Cell Transplant · 2023

Stem Cell Transplant for Plasma Cell Dyscrasias

Sanjeev Kumar Sharma · Basics of Hematopoietic Stem Cell Transplant · 2023

Stem Cell Transplant for Myelofibrosis

Sanjeev Kumar Sharma · Basics of Hematopoietic Stem Cell Transplant · 2023

Chimerism Post stem Cell Transplant

Sanjeev Kumar Sharma · Basics of Hematopoietic Stem Cell Transplant · 2023

B Cells

Sanjeev Kumar Sharma · Basics of Hematopoietic Stem Cell Transplant · 2023

Showing 11 of 22 known citations — external sources report more than can currently be individually listed.

Article metrics

Real usage data collected on this platform.

69

Page views

0

PDF downloads

7

Outbound clicks

22

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.