What a Clinical Hematologist should Know about B Cells?
International Blood Research & Reviews · pp. 8–22 · Published 10 Jan 2022
10.9734/ibrr/2022/v13i130166Abstract
B cells are very crucial part of our immune system. They protect us from various infections by secreting antigen-specific antibodies, which neutralize the infectious agents. It is important for a clinical hematologist to know about the B cell development, function and the diseases developing from the quantitative or qualitative defects in B cells. This simple and short review is focused on the basic understanding and clinical hematologist’s perspective of B cells.
References (43)
- 1 WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
- 2 Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [DOI]
- 3 Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray [DOI]
- 4 Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme [DOI]
- 5 B lymphocytes: how they develop and function [DOI]
- 6 An introduction to immunology and immunopathology [DOI]
- 7 Germinal Center B Cell Dynamics [DOI]
- 8 Germinal-Center Organization and Cellular Dynamics [DOI]
- 9 Mechanisms of B-cell lymphoma pathogenesis [DOI]
- 10 Germinal centres: role in B-cell physiology and malignancy [DOI]
- 11 B-cell biology and development [DOI]
- 12 The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry [DOI]
- 13 Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation [DOI]
- 14 The establishment of resident memory B cells in the lung requires local antigen encounter [DOI]
- 15 RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia [DOI]
- 16 Thymus-Independent and Thymus-Dependent Responses to Polysaccharide Antigens [DOI]
- 17 Regulatory Mechanisms that Determine the Development and Function of Plasma Cells [DOI]
- 18 Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma [DOI]
- 19 Commitment of B Lymphocytes to a Plasma Cell Fate Is Associated with Blimp-1 Expression In Vivo [DOI]
- 20 Molecular Mechanisms of Somatic Hypermutation and Class Switch Recombination [DOI]
- 21 The Maintenance of Memory Plasma Cells [DOI]
- 22 A new vision of immunity: homeostasis of the superorganism [DOI]
- 23 High grade B-cell lymphoma with rearrangements of MYC and BCL2 and/or BCL6: Double hit and triple hit lymphomas and double expressing lymphoma [DOI]
- 24 Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia [DOI]
- 25 The oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B-cell lymphomas [DOI]
- 26 Guidelines for the management of diffuse large B‐cell lymphoma [DOI]
- 27 How I treat posttransplant lymphoproliferative disorders [DOI]
- 28 Background to hematopoietic cell transplantation, including post transplant immune recovery [DOI]
- 29 Immune reconstitution and implications for immunotherapy following haematopoietic stem cell transplantation [DOI]
- 30 Plasma cell differentiation during the germinal center reaction [DOI]
- 31 What a Clinical Hematologist Should Know about T Cells? [DOI]
- 32 Thymus-Marrow Cell Combinations. Synergism in Antibody Production. [DOI]
- 33 Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts [DOI]
- 34 Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts [DOI]
- 35 B cell reconstitution after human bone marrow transplantation: recapitulation of ontogeny?
- 36 Repression of BCL-6 is required for the formation of human memory B cells in vitro [DOI]
- 37 Characteristic Pattern of Chromosomal Imbalances in Posttransplantation Lymphoproliferative Disorders: Correlation with Histopathological Subcategories and EBV Status [DOI]
- 38 Principles of innate and adaptive immunity
- 39 Pre-B cell receptor–mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC [DOI]
- 40 Aggressive B-cell lymphomas—from morphology to molecular pathogenesis [DOI]
- 41 Antigen receptor diversification and chromosome translocations [DOI]
- 42 Role of the surrogate light chain and the pre‐B‐cell receptor in mouse B‐cell development [DOI]
- 43 Pre-B Cell Receptor-Mediated Activation of BCL6 Induces Pre-B Cell Quiescence Through Transcriptional Repression of MYC [DOI]
Cited by 22
Sanjeev Kumar Sharma · Basics of Hematopoietic Stem Cell Transplant · 2023
Sanjeev Kumar Sharma · Basics of Hematopoietic Stem Cell Transplant · 2023
Sanjeev Kumar Sharma · Basics of Hematopoietic Stem Cell Transplant · 2023
Sanjeev Kumar Sharma · Basics of Hematopoietic Stem Cell Transplant · 2023
Sanjeev Kumar Sharma · Basics of Hematopoietic Stem Cell Transplant · 2023
Sanjeev Kumar Sharma · Basics of Hematopoietic Stem Cell Transplant · 2023
Sanjeev Kumar Sharma · Basics of Hematopoietic Stem Cell Transplant · 2023
Sanjeev Kumar Sharma · Basics of Hematopoietic Stem Cell Transplant · 2023
Sanjeev Kumar Sharma · Basics of Hematopoietic Stem Cell Transplant · 2023
Sanjeev Kumar Sharma · Basics of Hematopoietic Stem Cell Transplant · 2023
Showing 11 of 22 known citations — external sources report more than can currently be individually listed.
Related research
- Maternal Nutrition and Fetal Programming of the Immune System: Epidemiological and Experimental Evidences — shares topic coverage
- Reports on COVID-19 Vaccines and Vaccination in Nigeria — shares topic coverage
- Consumption of Escamoles (Liometopum apiculatum M.): A Source of Vitamins A and E — shares topic coverage
- Psychological Benefits of Sports and Physical Activities — shares topic coverage
- A Review on Medical Properties on Spirulina and Their Futuristic Applications — shares topic coverage
Article metrics
Real usage data collected on this platform.
69
Page views
0
PDF downloads
7
Outbound clicks
22
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.