Histo-architectural and Renal Function Markers in Long Term Consumption of Instant Noodles in Adult Wistar Rats

Abstract

This study investigated the morphological and biochemical changes in the kidney of adult wistar rats fed with instant noodles. Fifty (50) adult wistar rats of an average of 180g were procured for the study. After two weeks of acclimatization, the rats were randomly grouped into five (5) (A, B, C, D and E) of ten (10) rats per group. Group A animals were fed with cooked instant noodle (Type A), group B rats received cooked instant noodles with its spice, group C received cooked noodle (type B) only, and group D animals received cooked instant noodles (type B) with its spice while group E (control animals received grower marsh for thirty (30) days. At the end of the administration of test substances, the animals were sacrifice by cervical dislocation and kidney tissue harvested and subjected to histological technique. Assay of selected renal function markers [Urea and Creatinine levels] was also conducted using serum. Statistical Package for Social Sciences (SPSS version 21) was used to evaluate the data obtained. Results (H&E) revealed that there was an enlarge Bowman’s space distortion and disruption  of  the cyto-architecture of  the renal cortical structure and marked sign of diffuse nephritis  of treated animals as compared to the control animal but with that  of  treated group B more marked. Study also found a statistically significant increase in             serum urea levels of groups B, C and D wistar rats as compared to control; whilst observing a significant increase in serum creatinine levels of groups A and D wistar rats only as against the control (group E). Further study aimed at corroborating the findings from this work should be encouraged.