Cyclic Voltammetric Study of Clarithromycin Using Gold Electrode

Abstract

Clarithromycin is biologically active compound which is belonging to the class of antifungal compound. This is used for the treatment of HIV patients. In present study the electrochemical parameters of clarithromycin has been carried out through cyclic voltammetry technique. These parameters have been studied in presence of Briton Robinson buffer pH range (2-6) has been selected according to the appropriate solubility of clarithromycin. Voltammograms of the clarithromycin have been recorded at six different scan rates of 20, 100, 200, 300, 400 and 500mV/s. Different electrochemical parameters such as peak potential (Ep), peak current (Ip), transfer coefficient (α), number of electron (nα), diffusion coefficient (D), and heterogeneous rate constant (K0) were determined. Moreover, diagnostics tests have also been applied to define the electrochemical properties of these compounds. In case of Clarithromycin irreversible oxidation process with two electron transfer has been identified and electrode processes were shown to be diffusion controlled.