Monomorphic T-Cell Post-Transplant Lymphoproliferative Disorder: A Case Report

Abstract

The study reports a case of T-cell PTLD in a kidney recipient with a review of literature. Solid organ or bone marrow transplantation is the only curative treatment for a variety of diseases. Paradoxically, it accounts for several potentially life-threatening complications for the recipient that are often inevitable. A 53-year-old male patient presented to our hospital with dry cough and high-grade fever of 1 day duration. The patient had a history of diabetes mellitus and hypertension that were complicated by end-stage renal disease and hemodialysis until he underwent kidney transplant 3 years prior to presentation. Diagnostic thoracentesis was performed, and according to light’s criteria, the pleural fluid was consistent with lymphocytic exhudate. This result raised the concern of an underlying malignancy (PTLD in particular) which necessitated a tissue biopsy in order to be confirmed. The patient was started on chemotherapy with CHOP protocol (Doxorubicin, cyclophosphamide, Vincristine, and Prednisone).