Evaluation of Formulated Suspension with Varying Concentrations of Pectin Derived from Mango (Mangifera indica Linn.) Peel and Acacia (Acacia Senegal L.) as Suspending Agents

Abstract

Background: Nature has provided us a wide variety of materials to help improve and sustain the health of all living things either directly or indirectly. Pharmaceutical excipients used as suspending agents from natural sources are preferable due to their biocompatibility, abundance, and positive impact on the environment. Mangifera indica peel is excessively produced as a by-product of local food processing plants in Cebu. The objective of the study is to characterize the formulated suspensions with varying concentration of pectin from mango peel and acacia (Acacia Senegal L) as a suspending agent. Objective: Determine the characteristics of the formulated suspensions with varying concentrations of pectin from mango peel and acacia as suspending agents Methods: Paracetamol suspensions were prepared with mango pectin at concentrations of 2, 3 and 4 % and acacia (3%) as standard. The prepared suspensions were characterized based on sedimentation volume, degree of flocculation, flow rate, pH, viscosity and redispersibility. Results and discussions: Mango pectin exhibited good sedimentation volume and viscosity-enhancing property, qualities which are important as a suspending agent in pharmaceutical suspensions. Conclusion: The present review provided an overview of various aspects of natural suspending  agent like general  extraction  method, physicochemical  properties which supported the possible utility of mango peel derived pectin as a potential biomaterial in formulating pharmaceutical suspensions.