Uses of 1-Cyanoacetyl-4-Phenyl-3-Thiosemicarbazide in the Synthesis of Antimicrobial and Antifungal Heterocyclic Compounds
Rafat M. Mohareb, Abeer A. Mohamed
International Research Journal of Pure and Applied Chemistry · pp. 144–155 · Published 4 Jul 2012
10.9734/IRJPAC/2012/1334Abstract
The thiosemicarbazide synthesized from the reaction of cyanoacetylhydrazine phenylisothiocyanate reacted with acetoacetanilide gave the 2-pyridinone derivative 4. The reaction of the latter product with 1,3-dicarbonyl and α-halocarbonyl compounds gave the benzo[c]pyridine derivatives 6a,b and the thiazole derivatives 9a,b, respectively. The reaction with phenylisothiocyanate and elemental sulfur gave the thiazole derivative 14. The latter compound reacted with α-halocarbonyl compounds to give the thiazole products 16a-c. The antimicrobial and antifungal evaluations of the newly synthesized products showed that some compounds have high activity.
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