Ursodeoxycholic Acid (UDCA) in Biliary Diseases: A Clinical Review
Journal of Advances in Medicine and Medical Research · pp. 1783–1790 · Published 9 Jan 2014
10.9734/BJMMR/2014/7186Abstract
Ursodeoxycholic acid (UDCA) is an established and accepted treatment of biliary diseases such as gallstones and primary biliary cirrhosis. Mechanisms of action of UDCA are not so far completely elucidated. UDCA tablets are indicated for the dissolution of small to medium sized radiolucent, cholesterol-rich gall-stones in patients with a functioning gall bladderand in the treatment of primary biliary cirrhosis (PBC). The Food and Drug Administration's Gastrointestinal Drugs Advisory Committee has stated that UDCA is safe and effective for the treatment of primary biliary cirrhosis. More recent Meta-analysis have cast doubt on the real impact of UDCA in patients with PBC. However more recent articles and systematic reviews have pointed out that the risk of death or liver transplantation was reduced by 32% in PBC patients treated with UDCA compared to placebo. In this review we summarized the principal evidence of efficacy of UDCA in the treatment of biliary diseases. UDCA remains so far a relevant pharmacological treatment in biliary diseases.
Cited by 14
A. Lopalco, O. Boscolo, A. Cutrignelli · Pharmaceutics · 2026
Thamer Abdulla Mohammed, M. H. Zalzala · Naunyn-Schmiedeberg's Archives of Pharmacology · 2025
Prathita Amanda, Erik Prabowo, M. Muniroh · Open Access Macedonian Journal of Medical Sciences · 2022
J. Golden, Oswaldo H. Escobar, Michelle V. L. Nguyen · American Journal of Physiology - Gastrointestinal and Liver Physiology · 2018
Peiying Zuo, R. Dobbins, R. O'Connor-Semmes · CPT: Pharmacometrics & Systems Pharmacology · 2016
V. A. Prikhodko, S. V. Okovityi · Experimental and Clinical Gastroenterology · 2023
Showing 6 of 14 known citations — external sources report more than can currently be individually listed.
Related research
- Challenges and Opportunities of Irrigation Practices in Ethiopia: A Review — shares topic coverage
- An Update on Fluorides and Fluorosis with Reference to Oral Health Status in the Gulf Region: Review — shares topic coverage
- Impact of COVID-19 on Cardiovascular Patients and Review of Current COVID-19 Treatment Strategies — shares topic coverage
- Infections of Cardiac Implantable Electronic Devices: Diagnosis and Approach — shares topic coverage
- A Comprehensive Review on Natural Products and Anti-Inflammatory Activity — shares topic coverage
Article metrics
Real usage data collected on this platform.
8
Page views
0
PDF downloads
0
Outbound clicks
14
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.