Upstreaming and Downstreaming Regulators and Associated Signaling Transduction Pathways of AKT/PKB: A Molecular Gateway to Progressive Carcinoma

References (41)

1. 1 Targeting PI3K/Akt signal transduction for cancer therapy [DOI]
2. 2 Targeting PI3K/Akt/mTOR Signaling in Cancer [DOI]
3. 3 Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis [DOI]
4. 4 Akt, FoxO and regulation of apoptosis [DOI]
5. 5 Structure and dynamics of GPCR signaling complexes [DOI]
6. 6 HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation [DOI]
7. 7 AKT plays a central role in tumorigenesis [DOI]
8. 8 Multiple Roles of the PI3K/PKB (Akt) Pathway in Cell Cycle Progression [DOI]
9. 9 Structure, regulation and function of PKB/AKT—a major therapeutic target [DOI]
10. 10 The PI3K/AKT/mTOR pathway in breast cancer: targets, trials and biomarkers [DOI]
11. 11 Analysis of anticancer drugs: A review [DOI]
12. 12 TGF- : Duality of Function Between Tumor Prevention and Carcinogenesis [DOI]
13. 13 The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change [DOI]
14. 14 Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer [DOI]
15. 15 The emerging multiple roles of nuclear Akt [DOI]
16. 16 Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis [DOI]
17. 17 Mdm2 phosphorylation by Akt regulates the p53 response to oxidative stress to promote cell proliferation and tumorigenesis [DOI]
18. 18 PI3K-AKT-mTOR and NFκB Pathways in Ovarian Cancer: Implications for Targeted Therapeutics [DOI]
19. 19 The Role of AKT/mTOR Pathway in Stress Response to UV-Irradiation: Implication in Skin Carcinogenesis by Regulation of Apoptosis, Autophagy and Senescence [DOI]
20. 20 GPCRs and cancer [DOI]
21. 21 PI3K/Akt and caspase pathways mediate oxidative stress-induced chondrocyte apoptosis [DOI]
22. 22 Orchestrated modulation of rheumatoid arthritis via crosstalking intracellular signaling pathways [DOI]
23. 23 Cdk inhibitors in development and cancer [DOI]
24. 24 The role of p53 and pRB in apoptosis and cancer [DOI]
25. 25 Akt Inhibits the Orphan Nuclear Receptor Nur77 and T-cell Apoptosis [DOI]
26. 26 Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt [DOI]
27. 27 G protein‐coupled receptor‐induced Akt activity in cellular proliferation and apoptosis [DOI]
28. 28 Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Activates the WNK-OSR1/SPAK-NCC Phosphorylation Cascade in Hyperinsulinemic db/db Mice [DOI]
29. 29 Novel targets of Akt, p21, and MDM2 [DOI]
30. 30 Cancer Stem Cell-Like Phenotype and Survival Are Coordinately Regulated by Akt/FoxO/Bim Pathway [DOI]
31. 31 Targeting RAS and PI3K in lung cancer [DOI]
32. 32 WNK pathways in cancer signaling networks [DOI]
33. 33 Nur77: a potential therapeutic target in cancer [DOI]
34. 34 WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis [DOI]
35. 35 GLI1 reduces drug sensitivity by regulating cell cycle through PI3K/AKT/GSK3/CDK pathway in acute myeloid leukemia [DOI]
36. 36 Special Issue “Anticancer Drugs” [DOI]
37. 37 PI3K-AKT-FoxO axis in cancer and aging [DOI]
38. 38 Predicting ligand binding poses for low-resolution membrane protein models: Perspectives from multiscale simulations [DOI]
39. 39 Hippo Signaling Pathway as a Central Mediator of Receptors Tyrosine Kinases (RTKs) in Tumorigenesis [DOI]
40. 40 Receptor tyrosine kinase structure and function in health and disease [DOI]
41. 41 Signal Transduction and Targeted Therapy [DOI]

Cited by 2

Showing 1 of 2 known citations — external sources report more than can currently be individually listed.