Update on COVID-19 Infection and Ivermectin Treatment
Konne Felix Eedee, Emeji Roseline
International Journal of Pathogen Research · pp. 9–16 · Published 13 May 2021
10.9734/ijpr/2021/v7i130172Abstract
Coronaviruses are a group of related RNA viruses that cause disease in mammals and birds. COVID-19 infection is caused by a single stranded RNA virus called SARS-CoV-2 that is similar to the severe acute respiratory syndrome coronavirus (SARS-CoV). The aim of this review is to identify how COVID-19 infects man, the preventive approach and treatment possibility with ivermectin drug. The possible main source of transmission is thought to be a close contact with infected person or animal and respiratory droplets while the mucous membrane; conjunctiva, mouth, nasal cavity, and throat are the main routes of transmission. The virus enters the human through the ACE2 receptor which are found in the mucous membrane. This is an important step for coronavirus infection establishment. To stay safe from coronavirus, physical distancing, wearing of face mask, keeping rooms well ventilated, avoiding crowds, cleaning/washing your hands, the use of hand sanitizers and coughing into a bent elbow are precautionary measures to avoid contracting the infection. Ivemectin blocks the initiation of the binding of the viral protein to the cytoplasmic receptor (imp α/β). The inhibitory role of ivemectin prevents further increase in the viral load. Ivermectin drug could be a remarkable medical breakthrough for the lasting treatment of the infection; however, more clinical trials are suggested in this area.
References (42)
- 1 Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [DOI]
- 2 A pneumonia outbreak associated with a new coronavirus of probable bat origin [DOI]
- 3 Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study [DOI]
- 4 La certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19
- 5 A new coronavirus associated with human respiratory disease in China [DOI]
- 6 Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding [DOI]
- 7 Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro [DOI]
- 8 First Case of 2019 Novel Coronavirus in the United States [DOI]
- 9 The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health — The latest 2019 novel coronavirus outbreak in Wuhan, China [DOI]
- 10 Coronaviruses: An Overview of Their Replication and Pathogenesis [DOI]
- 11 Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan [DOI]
- 12 The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro [DOI]
- 13 Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC [DOI]
- 14 Coronaviruses post-SARS: update on replication and pathogenesis [DOI]
- 15 Viral load of SARS-CoV-2 in clinical samples [DOI]
- 16 Updated understanding of the outbreak of 2019 novel coronavirus (2019‐nCoV) in Wuhan, China [DOI]
- 17 Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020 [DOI]
- 18 Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response [DOI]
- 19 Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS‐CoV‐2 infection [DOI]
- 20 2019-nCoV transmission through the ocular surface must not be ignored [DOI]
- 21 Coronavirus Genomics and Bioinformatics Analysis [DOI]
- 22 Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans [DOI]
- 23 Enteric involvement of coronaviruses: is faecal–oral transmission of SARS-CoV-2 possible? [DOI]
- 24 Bat Coronaviruses in China [DOI]
- 25 Coronavirus Disease - COVID-19 [DOI]
- 26 Ocular Tropism of Respiratory Viruses [DOI]
- 27 Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease [DOI]
- 28 Genetic Characterization of Betacoronavirus Lineage C Viruses in Bats Reveals Marked Sequence Divergence in the Spike Protein of Pipistrellus Bat Coronavirus HKU5 in Japanese Pipistrelle: Implications for the Origin of the Novel Middle East Respiratory Syndrome Coronavirus [DOI]
- 29 Evidence Supporting a Zoonotic Origin of Human Coronavirus Strain NL63 [DOI]
- 30 Feigin & Cherry's textbook of pediatric infectious diseases
- 31 Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in rhesus macaques [DOI]
- 32 SARS-related Virus Predating SARS Outbreak, Hong Kong [DOI]
- 33 Transmission Routes Analysis of SARS-CoV-2: A Systematic Review and Case Report [DOI]
- 34 ANCA-Associated Vasculitis — Refining Therapy with Plasma Exchange and Glucocorticoids [DOI]
- 35 Evidence Supporting a Zoonotic Origin of Human Coronavirus Strain NL63 [DOI]
- 36 Diagnosis of Severe Acute Respiratory Syndrome (SARS) by Detection of SARS Coronavirus Nucleocapsid Antibodies in an Antigen-Capturing Enzyme-Linked Immunosorbent Assay [DOI]
- 37 Feigin and Cherry's Textbook of Pediatric Infectious Diseases [DOI]
- 38 Molecular Evolution Analysis and Geographic Investigation of Severe Acute Respiratory Syndrome Coronavirus-Like Virus in Palm Civets at an Animal Market and on Farms [DOI]
- 39 SARS-CoV and emergent coronaviruses: viral determinants of interspecies transmission [DOI]
- 40 Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody [DOI]
- 41 Ophthalmologic evidence against the interpersonal transmission of 2019 novel coronavirus through conjunctiva [DOI]
- 42 The infection evidence of SARS-COV-2 in ocular surface: a single-center cross-sectional study [DOI]
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