Update in the Relationship between Gut Microbiota and Kawasaki Disease
Fuyong Jiao, Xiaojin Ding, Jianying Feng, Juyan Wang, Ling Zhang
International Journal of TROPICAL DISEASE & Health · pp. 27–31 · Published 10 Jun 2022
10.9734/ijtdh/2022/v43i1230630Abstract
Kawasaki disease (KD) is an acute febrile systemic necrotizing medium and small vasculitis in children, mainly affecting children under 5 years old, and has become the main cause of pediatric acquired heart disease in developing countries. The exact etiology of this disease is still unclear. At present, researcheson KD are mostly limited to susceptibility gene, infection and immunity. How ever, there are few studies on the correlation between intestinal flora and KD. In recent years, some studies have found that KD is related to the imbalance of intestinal flora, and the abundance and structure of intestinal flora in children with KD change, which contributes to the occurrence and development of KD by affecting the release of inflammatory factors, damaging the intestinal barrier function and activating the autoimmune system. This review aims to elucidate the relationship between gut microflora and KD, and the mechanism of action and that of probiotics
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