Protective Effect of Costus afer on Lipid Profile and Hepatic Damage in Ethanol - Induced Liver Cirrhosis in Rats
Ayakeme Tonkiri, E. B. Essien, J. O. Akaninwor, Ronami S. Ogbomade
International Journal of Biochemistry Research & Review · pp. 53–61 · Published 5 Jan 2015
10.9734/IJBCRR/2015/14577Abstract
Aim: The study is to investigate the impact of Costus afer methanolic stem extract on lipid metabolic profiles and bilirubin levels in alcohol-induced liver cirrhosis progression in rats. Materials and Methods: Male wistar strain albino rats were randomly divided into five groups: Control (normal feed and water only), Costus afer control (CA), Ethanol control (Ethanol), ethanol + Costus afer (60mg) treated rats (CA + ETHANOL) and ethanol + Costus afer (120mg) treated rats (CACA + ETHANOL). Serum levels of lipids and bilirubin were measured. Results: The result showed that ethanol only administration caused triglyceride, cholesterol, low density lipoprotein and bilirubin to increase by 46.1%, 64.3%, 10.71% and 0.18% respectively compared to control rats (p<0.05). High density lipoprotein was shown to have decreased by 11.2% compared to the control. Conclusion: Evidence suggests that oxidative stress is involved in the pathophysiology of complications and alcoholic diseases. Co-treatment with the extract modestly modulates the effect of ethanol to near normal.
Cited by 4
M. Hegazy, O. Abonama, Asmaa N. Mohammad · 2020
A. Jimoh, B. Maiha, B. Chindo · 2020
A. Ekanem, K. Udoh, A. Peter · International Journal of Advanced Research · 2018
U. Kp, E. Au, Peter Ai · 2018
Related research
- The Prevalence of Prediabetes and Its Association with Metabolic Syndrome and Insulin Resistance in the Central Indian Population — shares topic coverage
- Cholesterol and Fatty Acid Profiles of Some Bird Egg Varieties: Possible Health Implications — shares topic coverage
- Effect of Estradiol Valerate on Serum Biochemical Profiles in Aged Female Albino Rats — shares topic coverage
- The Effect of Pleurotus tuberregium (An Oyster Mushroom) Sclerotia on the Weight, Protein Content and Lipid Profile of Broiler Chickens — shares topic coverage
- Total Cholesterol and Triglycerides in Unmarried Males and Females of Azad Jammu and Kashmir, Pakistan — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
4
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.