Unveiling the Biomedical Potential of Hypnea valentiae: Isolation and Characterization of Phytochemicals with Anticancer Activity

Abstract

Biologically active chemicals with anticancer properties have been discovered in marine Rhodophyceae seaweed Hypnea valentiae, coastal red algae species, was obtained from the coasts of Porbandar and Kuchhdi, Gujarat, India. In this present study, marine red algae Hypnea valentiae extract is used for the analysis of physicochemical, phytochemical Chromosomal Aberrations and MTT anti-cancer activity. Despite tremendous advancements in medicine, infectious diseases continue to pose a significant threat to public health. Various synthetic medications have developed resistance to infectious diseases in recent years. As a result, medicinal plants contain a variety of phytochemicals that can be used to treat a variety of oxidative stress-related diseases. The Proanthocyanidin content of Hypnea valentiae (0.11mg/g) and physicochemical parameter like of moisture in the seaweed was 88.98 %, the amount of ash was 16.95 % and Carbonated ash accounted for 26.67%. The physicochemical parameters like different ash values and moisture content are plant-specific and they help to ensure the purity of the drug and also prevent adulteration. MTT assay against HeLa cell line human cervical cancer was used to estimate cell viability and outcomes showed excellent results against HeLa cell lines Human cervical cancer cell lines. In our experiment on Chromosomal Aberrations Seaweed H. valentinea cannot damage normal chromosomes and cannot affect any part of chromosomes or chromatin. Based on these results, it is concluded that the marine macro seaweed extracts from the Gujarat coast have cytotoxic against cancer cells and have potential, which could be considered for identifying novel natural drugs and future applications in medicine from the marine resources.