Toxicological Effects of Antituberculosic Chemotherapy in Adults: An Integrative Literature Review
Viviane Ferraz Ferreira de Aguiar, Dayara de Nazaré Rosa de Carvalho, Dandara de Fátima Ribeiro Bendelaque, Lorena Nayara Alves Neves, Celice Ruanda Oliveira Sobrinho, Paula Sousa da Silva Rocha, Rafael Everton Assunção Ribeiro da Costa, Cidianna Emanuelly Melo do Nascimento, Susi dos Santos Barreto de Souza, Marcela Raíssa Asevedo Dergan, Mioni Thieli Figueiredo Magalhães Brito, Juarez Antônio Simões Quaresma
Journal of Pharmaceutical Research International · pp. 50–65 · Published 7 Apr 2021
10.9734/jpri/2021/v33i21A31368Abstract
Objective: To analyze the toxicological effects of anti-tuberculosis chemotherapy in adults in national and international literature in the period from 2015 to 2020. Methodology: It is a qualitative descriptive research, of the type Integrative Literature Review (ILR). In the VHL databases PubMed / Medline, Arca, Web of Science, Microsoft Academic and Cochrane Library. Data analysis was performed with the aid of the IRaMuTeQ software. Results: 36 articles were found in which the following categories were created: 1) Association of hepatotoxicity and appearance of liver damage; 2) The incidence of adverse events related to antituberculin therapy; 3) Risk factors of regular consumption of antituberculins; 4) Intensive renal treatment for patients with nephrotoxicity. Conclusion: in our review we identified that the elderly, HIV positive and alcohol users are more likely to have toxicological effects during treatment, which can lead to a possible abandonment of treatment.
Cited by 2
Pooja Jatav, Ruchi Khare Shrivastava · International Journal of Newgen Research in Pharmacy & Healthcare · 2024
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