Synthesis, Spectral Characterization, DNA Binding, Cleavage and Biological Evaluation on Co(II), Ni(II) and Cu(II) Complexes of Substituted Isoxazole Schiff Bases
Gali Ramesh, Marri Pradeep Kumar, Aveli Rambabu, Narendrula Vamsikrishna, Sreenu Daravath, Shivaraj .
Asian Journal of Chemical Sciences · pp. 1–20 · Published 21 May 2018
10.9734/AJOCS/2018/41465Abstract
A series of [Co(LI)2] (1), [Ni(LI)2] (2), [Cu(LI)2] (3), [Co(LII)2] (4), [Ni(LII)2] (5) and [Cu(LII)2] (6) complexes where LI = 2-((E)-(5-(4-fluorophenyl)isoxazol-3-ylimino)methyl)-5-methoxyphenol and LII = 2-((E)-(5-(4-fluorophenyl)isoxazol-3-ylimino)methyl)-4-bromophenol, were synthesized and characterized by elemental analysis, Infrared, UV–visible, Nuclear magnetic resonance, Mass spectral studies, Electron Spin Resonance, Thermogravimetric analysis, Magnetic moment, Scanning Electron Microscope and Powder X-ray Diffraction analyses. From the analytical results, all these metal (II) complexes are assigned to square planar geometry around the metal ions. The DNA-binding and cleavage studies were evaluated for the synthesized compounds with CT–DNA and supercoiled pBR322 DNA, respectively. All compounds have been monitored for their in Vitro antimicrobial assay.
Cited by 2
P. Priya, S. Vedanayaki, P. Jayaseelan · Asian Journal of Chemistry · 2019
Gali Ramesh, Sreenu Daravath, M Swathi · Chemical Data Collections · 2020
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