The Effect of Ginger on the Invasion and  Migration of Glioma Cells

Manar Zraikat; Munir Gharaibeh; Tasneem Alshelleh

doi:10.9734/ejmp/2020/v31i1030279

Research Article Open access CC BY 4.0

The Effect of Ginger on the Invasion and Migration of Glioma Cells

Manar Zraikat, Munir Gharaibeh, Tasneem Alshelleh

European Journal of Medicinal Plants · pp. 38–43 · Published 3 Jul 2020

10.9734/ejmp/2020/v31i1030279

Abstract

Background: This work studies the effect of different concentrations of soaked ginger on the ability of the U87 glioma cells to invade collagen in a three dimension (3 D) invasion model and compare it with its effect on the ability of the same cell line to migrate in two-dimension (2 D) scratch assay. Methods: The hanging drop spheroids in 3D invasion assay were used to investigate the in invasion of the U87 cells. The 2D scratch assay was used to investigate the migration of the same cell line. Results: Gradual effect of the soaked ginger was noticed on the inhibition of the invasion of U87 in collagen and on the inhibition of the migration of the same cell line in scratch assay. Conclusion: The results in this article are promising and encourage further studies to investigate the effect of ginger active ingredients on tumour progression.

Invasion cancer migration assay

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Manar Zraikat, Munir Gharaibeh, Tasneem Alshelleh (2020). The Effect of Ginger on the Invasion and Migration of Glioma Cells. European Journal of Medicinal Plants , 38–43. https://doi.org/10.9734/ejmp/2020/v31i1030279

Affiliations

Manar Zraikat — Department of Pharmacology, School of Medicine, The University of Jordan, Amman, Jordan.
Munir Gharaibeh — Department of Pharmacology, School of Medicine, The University of Jordan, Amman, Jordan.
Tasneem Alshelleh — Department of Pharmacology, School of Medicine, The University of Jordan, Amman, Jordan.

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