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Research Article Open access CC BY 4.0

Therapeutic Potential of Carica papaya Linn.: A Comprehensive Review of Its Pharmacological Properties and Health Benefits, with Emphasis on Dengue Fever Healing

D. T. K. Fernando, D. S. H. S. Peiris, S. P. N. N. Senadeera, C. B. Ranaweera

Asian Plant Research Journal · pp. 32–48 · Published 21 Feb 2024

10.9734/aprj/2024/v12i1242

Abstract

For thousands of years, people have used various plant products, foods, spices, and herbs to treat and prevent illnesses. Sri Lankans have been using traditional and folk medicine to satisfy their basic health needs from the earliest days. Carica papaya Linn. (Caricaceae) is a commercially grown exotic plant in Sri Lanka. The entire plant, including the fruits both ripened and green, leaves, roots, peel, seed, and pulp, was used as medicine in traditional medicinal systems. Plant parts of Carica papaya Linn. were frequently used by ancient Sri Lankans to treat diabetes mellitus, hypertension, cancer, dengue fever, skin infections, renal disorders, and infections caused by bacteria, fungi, parasites, and viruses. Dengue fever is the most prevalent and significant arthropod-borne viral disease in humans, and it is extensively spread throughout Sri Lanka. Carica papaya Linn. extracts have been used to treat dengue patients to recover from its complications, which include thrombocytopenia, hemolysis, and leukopenia. Studies reveal that the papaya leaf extract can neutralize plasma with the dengue virus, reduce platelet aggregation, and increase the production of the enzyme ALOX12, which promotes platelet production. Moreover, the extract also upregulates the platelet-activating factor receptor (PTAFR) gene and inhibits serine proteases NS2B and NS3 involved in dengue virus replication. In this review, we have discussed extensively the ethnomedicinal and pharmacological properties of Carica papaya while highlighting its remarkable potency in healing dengue.

Carica papaya dengue Thrombocytopenia dengue hemorrhagic fever ethnomedicine phytochemical screening Sri Lanka

References (42)

  1. 1 Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects [DOI]
  2. 2 Traditional and Medicinal Uses of Carica papaya
  3. 3 Dengue fever treatment with Carica papaya leaves extracts [DOI]
  4. 4 Gas chromatography–mass spectrometry analysis of phenolic compounds from Carica papaya L. leaf [DOI]
  5. 5 Fractionation and purification of the enzymes stored in the latex of Carica papaya [DOI]
  6. 6 Therapeutic application of Carica papaya leaf extract in the management of human diseases [DOI]
  7. 7 The efficacy of Carica papaya leaf extract on some bacterial and a fungal strain by well diffusion method [DOI]
  8. 8 Identification and quantification of flavonoids in Carica papaya leaf and peroxynitrite-scavenging activity [DOI]
  9. 9 Carica papaya: comprehensive overview of the nutritional values, phytochemicals and pharmacological activities [DOI]
  10. 10 Ethnomedicinal uses, nutritional composition, phytochemistry and potential health benefits of Carica papaya [DOI]
  11. 11 Effect of green and ripe Carica papaya epicarp extracts on wound healing and during pregnancy [DOI]
  12. 12 Papaya Seed Represents a Rich Source of Biologically Active Isothiocyanate [DOI]
  13. 13 Carotenoids in yellow‐ and red‐fleshed papaya (Carica papaya L) [DOI]
  14. 14 Benzylglucosinolate, Benzylisothiocyanate, and Myrosinase Activity in Papaya Fruit during Development and Ripening [DOI]
  15. 15 Antimalarial Potential of Carica papaya and Vernonia amygdalina in Mice Infected with Plasmodium berghei [DOI]
  16. 16 Traditional Aboriginal Preparation Alters the Chemical Profile of Carica papaya Leaves and Impacts on Cytotoxicity towards Human Squamous Cell Carcinoma [DOI]
  17. 17 Dengue Fever: Therapeutic Potential of Carica papaya L. Leaves [DOI]
  18. 18 BIOLOGICAL ACTIVITY OF CERTAIN BOTANICAL EXTRACTS AS LARVICIDES AGAINST THE YELLOW FEVER MOSQUITO, AEDES AEGYPTI.L [DOI]
  19. 19 Phytochemical Screening for Medicinal Plants: Guide for Extraction Methods [DOI]
  20. 20 Antioxidant Analysis of Different Parts of Several Cultivars of Papaya ( Carica Papaya L.) [DOI]
  21. 21 Mirabilis jalapa Linn.: A Folklore Ayurvedic Medicinal Plant in Sri Lanka [DOI]
  22. 22 In vitro Anti-Inflammatory Activity of Leaves of Jeffreycia zeylanica Using the Egg Albumin Denaturation Method and Human Red Blood Cell Stabilization Method [DOI]
  23. 23 Anti-inflammatory and antioxidant properties of unripe papaya extract in an excision wound model [DOI]
  24. 24 PHYTOCHEMICAL ANALYSIS OF PAW-PAW (CARICA PAPAYA) LEAVES
  25. 25 Papaya: A gifted nutraceutical plant - a critical review of recent human health research [DOI]
  26. 26 Effects of Coated Capillary Column, Derivatization, and Temperature Programming on the Identification of Carica papaya Seed Extract Composition Using GC/MS Analysis [DOI]
  27. 27 Evaluation of Antibacterial Activity of Endemic Jeffreycia zeylanica Plant Found in Sri Lanka [DOI]
  28. 28 A web-based multimedia spatial information system to document Aedes aegypti breeding sites and dengue fever risk along the US–Mexico border [DOI]
  29. 29 Extraction, isolation and characterization of bioactive compounds from chloroform extract of Carica papaya seed and it's in vivo antibacterial potentiality in Channa punctatus against Klebsiella PKBSG14 [DOI]
  30. 30 Pharmacological evidence for the folk use of Nefang: antipyretic, anti-inflammatory and antinociceptive activities of its constituent plants [DOI]
  31. 31 Ethanol extract of male Carica papaya flowers demonstrated non‐toxic against MCF‐7, HEP‐G2, HELA, NCI‐H460 cancer cell lines [DOI]
  32. 32 Clitoria ternatea - Shifting Paradigms: From Laboratory to Industry [DOI]
  33. 33 Lack of in vitro antihyaluronidase activity of methanolic leaf extract of Indigofera tinctoria L and methanolic stem bark extract of Stereospermum suaveolens DC [DOI]
  34. 34 Phytochemical study of the ethyl acetate extract of male Carica papaya flowers from Quang Nam – Da Nang [DOI]
  35. 35 First report of the molecular identification of a phytoplasma associated with dieback disease of papaya in Sri Lanka [DOI]
  36. 36 A Comprehensive Review of Salacia reticulata: Botanical, Ethnomedicinal, Phytochemical, and Pharmacological Insights [DOI]
  37. 37 Isolation And Purification Of Flavonoids From The Leaves Of Locally Produced Carica Papaya
  38. 38 IDENTIFICATION OF VIRUSES CAPABLE OF BREAKING TRANSGENIC RESISTANCE OF PAPAYA CONFERRED BY THE COAT PROTEIN GENE OF PAPAYA RINGSPOT VIRUS [DOI]
  39. 39 Crystallization and preliminary X-ray analysis of a protease inhibitor from the latex ofCarica papaya [DOI]
  40. 40 Yaşlı Kadınlarda Üreme Sağlığı
  41. 41 Journal of Pharmaceutical Negative Results [DOI]
  42. 42 Papaya (Carica papaya L.) Biology and Biotechnology

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