The Uromune Vaccine- A New Era in UTI Management: A Review

Abstract

Urinary Tract Infections (UTIs) are some of the most common bacterial infections. Urinary Tract Infections are categorized into uncomplicated and complicated. Urinary Tract Infections are symptomatic when there are clinical urinary symptoms that indicate infection such as micturition, dysuria, or pollakiuria. Urinary Tract Infections are recurrent when at least two episodes appear over a 6 months period, or three Over a 12 months period. The most prevalent location of UTI is the bladder, where they cause Cystitis. Women can be up to 30 times more predisposed than men to suffer from them. The antibiotics usually suggested are Sulfamethoxazole (200mg), Trimethoprim (40mg), Nitrofurantoin (100mg). Prolonged consumption of antibiotics is not free of side effects. They can damage the intestinal microbiota and favor the emergence of bacterial resistance. In view of this situation and as an alternative to the antibiotics for the prevention of uncomplicated recurrent UTI, The researchers at the Royal Burshire Hospital in England have developed a straightforward vaccine to treat this urinary tract infection. This vaccine called ‘Uromune’ should be sprayed under the tongue. This vaccine enters other mucosal parts of the body and fight against 88 types of bacteria that cause UTI. Vaccines are usually made with inactivated bacteria. But this vaccine doesnot kill bacteria in the body, it stops the bacteria from moving and keeps the bacterial protein intact.The human body’s immune system recognizes the protein and kills the non- motile bacteria.For nine years, this vaccine has been used in trials without any issues.