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Research Article Open access CC BY 4.0

The Study of Chemical, Mechanical, Thermal, and Morphological Properties of Poly Lactic Acid-nano Hydroxyapatite Composite Scaffold

Md Ruhul Amin Foisal, Ajoy Kumer, Umma Taslima Nasrin, Mohammad Ismail, Mohammad Saiful Alam

Chemical Science International Journal · pp. 1–11 · Published 21 May 2018

10.9734/CSJI/2018/41184

Abstract

Hydroxyapatite (HAp) ceramics have been recognized as substitute material in bone due to their chemical and biological similarity to human bone tissue. Nano HAp powders were synthesized by wet precipitation technique using aqueous suspension of 0.5 M calcium hydroxide [Ca(OH)2] with 0.3 M orthophosphoric acid [H3PO4] adding drop-wise and vigorously stirred to control the crystal size at nanoscale room temperature and pH 10.0were maintained to obtain a high purity of HAp. The HAp has been characterized and confirmed its nano crystal formation by X-ray diffraction (XRD). Then HAp has been pushed through polylactic acid (PLA) to make the composite scaffold blocks. Nano HAp-PLA composite scaffold blocks were produced by freeze drying. Different loading concentrations of nano-hydroxyapatite (nHAp) particles with the polylactic acid (PLA)fabricated scaffold blocks was investigated on their mechanical, thermal and morphological properties. The chemical and thermal properties of scaffold blocks were investigated by X-ray diffraction (XRD), the simultaneous thermo-gravimetric analyzer (TGA), the differential thermal analyzer (DTA) and thermos-mechanical analyzer (TMA). Crystallographic characterization was done by X-Ray diffraction and morphological characterization by scanning electron microscope. From the mechanical, thermal, chemical, and morphological analysis, it can estimate that the scaffold blocks possess microporous structure with 60% porosity having low moisture content 3% maximum, uniform nHAp distribution through scaffold block and15% HAp contained scaffold block possess maximum load holding ability.

Hap scaffold x-ray diffraction analysis thermo gravimetric analysis differential thermal analysis and thermo mechanical analysis

References (9)

  1. 1 Biomaterials for bone tissue engineering [DOI]
  2. 2 Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function [DOI]
  3. 3 Biodegradable polymer/hydroxyapatite composites: Surface analysis and initial attachment of human osteoblasts [DOI]
  4. 4 Amorphous calcium phosphate-based bioactive polymeric composites for mineralized tissue regeneration [DOI]
  5. 5 Biodegradation behavior of ultra-high-strength hydroxyapatite/poly (l-lactide) composite rods for internal fixation of bone fractures [DOI]
  6. 6 Effect of Micro- and Macroporosity of Bone Tissue Three-Dimensional-Poly(ɛ-Caprolactone) Scaffold on Human Mesenchymal Stem Cells Invasion, Proliferation, and Differentiation In Vitro [DOI]
  7. 7 Polymeric scaffolds as stem cell carriers in bone repair [DOI]
  8. 8 Enhanced Differentiation of Human Embryonic Stem Cells on Extracellular Matrix-Containing Osteomimetic Scaffolds for Bone Tissue Engineering [DOI]
  9. 9 Preparation of highly porous interconnected poly(lactic acid) scaffolds based on a novel dynamic elongational flow procedure [DOI]

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