Cell-Based Therapies in Musculoskeletal Injuries: The Evolving Role of Bone Marrow-Derived Mesenchymal Stem Cells
Journal of Advances in Medicine and Medical Research · pp. 486–500 · Published 28 Sep 2011
10.9734/BJMMR/2011/566Abstract
Aims: There is considerable interest in the potential of bone marrow-derived mesenchymal stem cells (BM-MSCs) in the management of musculoskeletal injuries. This review aims to summarise the information in the literature on the evolving role of these cells in the management of these complex heterogenous injuries. Study design: Review Article. Place and Duration of Study: University College London Institute of Orthopaedics and Musculoskeletal Sciences, Royal National Orthopaedic Hospital, Stanmore, Middlesex, HA7 4LP, United Kingdom. Methodology: We reviewed the literature to identify studies on the use of BM-MSCs for the management of musculoskeletal injuries. Results: There is an increasing and encouraging body of evidence to suggest that BM-MSCs have a significant role in the management of musculoskeletal injuries involving muscles, tendons, ligaments, bone, cartilage, menisci and nervous tissue. Conclusion: Several characteristics of BM-MSCs make them ideal candidates in managing musculoskeletal injuries. Bone marrow is easy to obtain requiring minimal donor site morbidity, invasiveness and anaesthetic. Their autologous nature eliminates the issue of immunoreactions and ethical problems. The majority of studies in the literature however use small animal models, and further work in larger animals and ultimately ethically approved clinical trials should be explored before any significant clinical relevance can be assessed.
References (70)
- 1 Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors [DOI]
- 2 THE DEVELOPMENT OF FIBROBLAST COLONIES IN MONOLAYER CULTURES OF GUINEA‐PIG BONE MARROW AND SPLEEN CELLS [DOI]
- 3 In VitroChondrogenesis of Bone Marrow-Derived Mesenchymal Progenitor Cells [DOI]
- 4 Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage. [DOI]
- 5 Adult Bone Marrow Stromal Cells Differentiate into Neural Cells in Vitro [DOI]
- 6 Tissue-engineered bone regeneration [DOI]
- 7 The knee meniscus: Structure–function, pathophysiology, current repair techniques, and prospects for regeneration [DOI]
- 8 Osteogenic Protein-1 (Bone Morphogenetic Protein-7) in the Treatment of Tibial Nonunions [DOI]
- 9 Bone regeneration by implantation of purified, culture‐expanded human mesenchymal stem cells [DOI]
- 10 Arthroscopy in acute traumatic hemarthrosis of the knee. Incidence of anterior cruciate tears and other injuries. [DOI]
- 11 In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis [DOI]
- 12 Achilles Tendon Injuries in Athletes [DOI]
- 13 Autologous Mesenchymal Stem Cell-Mediated Repair of Tendon [DOI]
- 14 Regenerative Effects of Transplanted Mesenchymal Stem Cells in Fracture Healing [DOI]
- 15 Implantation of bone marrow‐derived mesenchymal stem cells demonstrates improved outcome in horses with overstrain injury of the superficial digital flexor tendon [DOI]
- 16 Remyelination of the spinal cord following intravenous delivery of bone marrow cells [DOI]
- 17 Autologous Bone Marrow Transplantation in Patients with Subacute and Chronic Spinal Cord Injury [DOI]
- 18 Cartilage regeneration using mesenchymal stem cells and a three-dimensional poly-lactic-glycolic acid (PLGA) scaffold [DOI]
- 19 Osteoarthritis of weight bearing joints of lower limbs in former elite male athletes [DOI]
- 20 History of knee injuries and knee osteoarthritis: a meta-analysis of observational studies [DOI]
- 21 Mesenchymal stem cells [DOI]
- 22 Mesenchymal stem cells and insulin‐like growth factor‐I gene‐enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons [DOI]
- 23 Enhancement of tendon graft osteointegration using mesenchymal stem cells in a rabbit model of anterior cruciate ligament reconstruction [DOI]
- 24 In vivo achilles tendon loading' during jumping in humans [DOI]
- 25 Treatment of Complete Spinal Cord Injury Patients by Autologous Bone Marrow Cell Transplantation and Administration of Granulocyte-Macrophage Colony Stimulating Factor [DOI]
- 26 Treatment of Focal Articular Cartilage Defects in the Knee [DOI]
- 27 Repair of Large Articular Osteochondral Defects Using Hybrid Scaffolds and Bone Marrow-Derived Mesenchymal Stem Cells in a Rabbit Model [DOI]
- 28 Sources of Adult Mesenchymal Stem Cells Applicable for Musculoskeletal Applications - A Systematic Review of the Literature [DOI]
- 29 Use of Bone Marrow Stromal Cells for Tendon Graft-to-Bone Healing [DOI]
- 30 Analysis of return to competition and repeat rupture for 298 anterior cruciate ligament reconstructions with patellar or hamstring tendon autograft in sportspeople [DOI]
- 31 Reconstructive versus non-reconstructive treatment of anterior cruciate ligament insufficiency. A retrospective matched-pair long-term follow-up [DOI]
- 32 Human infrapatellar fat pad-derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor-2 [DOI]
- 33 Comparison of equine bone marrow-, umbilical cord matrix and amniotic fluid-derived progenitor cells [DOI]
- 34 Repair of cartilage defect in the rabbit with cultured mesenchymal stem cells from bone marrow [DOI]
- 35 A Clinical and Radiographical Analysis of 127 Anterior Cruciate Insufficient Knees [DOI]
- 36 Intra‐articular Injection of Mesenchymal Stromal Cells in Partially Torn Anterior Cruciate Ligaments in a Rat Model [DOI]
- 37 New technologies for the enhancement of skeletal repair [DOI]
- 38 A Novel, Biodegradable Polymer Conduit Delivers Neurotrophins and Promotes Nerve Regeneration [DOI]
- 39 Bone marrow‐derived mesenchymal stem cells express the pericyte marker 3G5 in culture and show enhanced chondrogenesis in hypoxic conditions [DOI]
- 40 The matrix-forming phenotype of cultured human meniscus cells is enhanced after culture with fibroblast growth factor 2 and is further stimulated by hypoxia [DOI]
- 41 Local administration of TGFβ-1/VEGF165 gene-transduced bone mesenchymal stem cells for Achilles allograft replacement of the anterior cruciate ligament in rabbits [DOI]
- 42 Meniscal repair by fibrocartilage in the dog: characterization of the repair tissue and the role of vascularity [DOI]
- 43 Advances in the Use of Stem Cells and Tissue Engineering Applications in Bone Repair [DOI]
- 44 New Strategies for Anterior Cruciate Ligament Partial Rupture Using Bone Marrow Transplantation in Rats [DOI]
- 45 Medial Meniscus Allograft Transplantation Using a Modified Bone Plug Technique: Clinical, Radiologic, and Arthroscopic Results [DOI]
- 46 Mesenchymal Stem Cells and Articular Cartilage Repair: Clinical Studies and Future Direction [DOI]
- 47 The Role of Bone Marrow-Derived Mesenchymal Stem Cells in Sports Injuries [DOI]
- 48 Cartilage Repair Strategies [DOI]
- 49 Osteogenic Protein-1 [DOI]
- 50 The role of stem cells, scaffolds and bioreactors in musculoskeletal tissue engineering
- 51 Multilineage Potential of Adult Human Mesenchymal Stem Cells [DOI]
- 52 The Effect of Implants Loaded with Autologous Mesenchymal Stem Cells on the Healing of Canine Segmental Bone Defects* [DOI]
- 53 Articular Cartilage Lesions in 993 Consecutive Knee Arthroscopies [DOI]
- 54 Current strategies for articular cartilage repair [DOI]
- 55 The use of bone-graft substitutes in large bone defects: Any specific needs? [DOI]
- 56 Knitted Poly-lactide-co-glycolide Scaffold Loaded with Bone Marrow Stromal Cells in Repair and Regeneration of Rabbit Achilles Tendon [DOI]
- 57 Ligament structure, physiology and function.
- 58 Patellar Tendinopathy in Athletes [DOI]
- 59 Hamstring Muscle Strains in Professional Football Players [DOI]
- 60 Stem cell based tissue engineering for meniscus repair [DOI]
- 61 A Tissue-Engineered Conduit for Peripheral Nerve Repair [DOI]
- 62 Meniscal repair using bone marrow-derived mesenchymal stem cells: experimental study using green fluorescent protein transgenic rats [DOI]
- 63 Tissue Engineering for Bone Production- Stem Cells, Gene Therapy and Scaffolds [DOI]
- 64 Regulation of Differentiation of Mesenchymal Stem Cells into Musculoskeletal Cells [DOI]
- 65 Meniscal Repair Supplemented With Exogenous Fibrin Clot and Autogenous Cultured Marrow Cells in the Goat Model [DOI]
- 66 Stem Cell Applications and Tissue Engineering Approaches in Surgical Practice [DOI]
- 67 Tissue Engineering in Orthopaedics and Musculoskeletal Sciences [DOI]
- 68 Advances and Developments in the Use of Human Mesenchymal Stem Cells – A Few Considerations [DOI]
- 69 The Effect of Changes in Oxygen Tension during Fracture Repair on Mesenchymal Stem Cell and Bone Activities
- 70 Hamstring muscle strains
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