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Research Article Open access CC BY 4.0

The Role of Genome Editing Technologies in Sustainable Agriculture

Prajyot Waghmode, Chetariya Chana Pitha, Vaishnavi Banka

Journal of Advances in Biology & Biotechnology · pp. 543–558 · Published 26 Jul 2024

10.9734/jabb/2024/v27i81168

Abstract

Genome editing technologies have emerged as powerful tools for making precise and targeted modifications in the DNA of living organisms, offering unprecedented opportunities to revolutionize agriculture amidst global challenges such as population growth, climate change, and diminishing resources. This review provides an overview of genome editing principles, its comparison with traditional breeding and genetic engineering methods, and the regulatory landscape governing its application. The CRISPR/Cas9 system, in particular, has revolutionized genome editing due to its efficiency, affordability, and versatility. By harnessing this system, researchers can induce specific modifications in plant genomes, enhancing traits such as yield, quality, and resilience to biotic and abiotic stresses. The review highlights recent advancements in CRISPR/Cas9 technology, including its adaptation for base editing and prime editing, which allow for precise nucleotide substitutions and broaden the scope of genetic modifications possible in crops. Addressing the regulatory environment surrounding genome-edited crops, the paper discusses existing regulations, international agreements, and ethical considerations. It emphasizes the need for science-informed regulations that balance innovation with transparency and public safety, crucial for fostering societal acceptance and facilitating global trade in genetically modified agricultural products. Furthermore, the review explores case studies and trends in genome editing applications across different crop species, illustrating how these technologies are being employed to address challenges in agriculture. From improving disease resistance to optimizing nutrient content and environmental adaptation, genome editing offers a pathway towards sustainable crop improvement. Looking forward, the review outlines future prospects and challenges in the field, including potential limitations such as off-target effects and the need for enhanced precision in editing techniques. It underscores the importance of integrating genome editing with conventional breeding methods to optimize agricultural productivity and resilience in the face of evolving environmental pressures. Genome editing holds immense promise for enhancing global food security and sustainability. By elucidating the current landscape of genome editing technologies and their applications in agriculture, this review aims to provide a comprehensive resource for policymakers, regulators, researchers, and the public, facilitating informed decision-making and supporting the responsible deployment of these transformative technologies in agriculture.

Genome editing CRISPR/Cas9 disease resistance nutrient content food security sustainability

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