The Role of 5-Hydroxytryptamine in Autism spectrum Disorder: Behavioral and Genetic Insights
Nojoud A. AL Ghamdi, Sheren A. Azhari, Reem M. Farsi
Journal of Pharmaceutical Research International · pp. 41–52 · Published 30 Jan 2025
10.9734/jpri/2025/v37i27654Abstract
Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition marked by challenges in social communication and repetitive behaviors. Although the exact cause of ASD is still unclear, various genetic and biochemical factors are known to play significant roles. Aim: This review focuses on the pivotal role of serotonin in ASD, emphasizing its connection to key behavioral symptoms and genetic influences. Methods: The search result from different online platform have been collected. Results: A notable biochemical characteristic of ASD is the dysregulation of serotonin, particularly hyperserotonemia, which correlates with variations in the SLC6A4 gene. Conclusion: The review highlights the necessity for further exploration of neurotransmitter pathways to better understand the pathophysiology of ASD and to support the development of targeted therapeutic strategies.
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