The Evaluation of Osteosarcoma and Ewing Sarcoma by Bone Markers in Children and Adult after Chemotherapy

Abstract

Background: In the east of Algeria, the rate of bone tumors is very high, unfortunately the Pathological Anatomy and radiology are not sufficient for evaluation and confirmation of the diagnosis. Bone alkaline phosphatase (BAP) and tartrate-resistant acid phosphatase (TRAP5b) were commonly elevated in Ostéosarcoma and Ewing sarcoma patients. The Ostéosarcoma is the most striking tumor in childhood and adolescence and Ewing sarcoma is the second bone tumor after the Ostéosarcoma. Evaluation and failure of the treatment is a major problem in the clinical practice of the bone sarcomas in Algeria. The objective of this study was to assess the serum BAP and TRAP5b levels and establish the relation between age and serum level of those markers in control population   and to study the bone tumors after chemotherapy with the correlation between the serum levels of BAP and TRAP5b before and after chemotherapy in children and adult. For this, a total of 73 patients: 40 Ostéosarcoma and 33 Ewing sarcoma aged 5-20 years, admitted in the hospital of Constantine named BENBADIS, between January 19, 2013 and January 03, 2015 and 100 patients aged 5- 20 years, as control population were reviewed in a prospective study. Bone alkaline phosphatase (BAP), was measured by using Ysis and tartrate-resistant acid phosphatase (TRAP5b), by Elisa kit. Results show that elevated serum levels of these markers are a very good prognostic factor of primary bone tumors as well as monitoring and evaluation tools, and the Difference of rate of markers before and after chemotherapy is good factor for the evaluation of bone sarcoma.  Bone markers BAP and TRAP5b can be used in the evaluation of bone tumors and to assess remodeling during chemotherapy for primary tumors in the children and the adults.