The Efficacy of Autologous Nanofat Versus Enhanced Nanofat with Adipose-Derived Stem Cells Transfers in the Treatment of Atrophic Post Acne Scars

Abstract

Background: Acne scarring is a visible reminder of acne vulgaris resulting from inappropriate healing of active lesions. Yet, no golden standard is present. Nanofat is an emulsified homogenous suspension of adipose tissue rich in adipose derived stem cells (ADSCs). Its application serves regenerative purposes. Objective: To evaluate efficacy of nanofat versus enhanced nanofat with adipose-derived stem cells transfer in treating atrophic acne scars. Methods and Materials: This study was carried on 40 patients with atrophic acne scars; grouped into two groups. Group A: 20 patients; treated with nanofat with platelet-rich plasma (PRP) and group B: 20 patients; treated with enhanced nanofat with ADSCs and PRP. Histopathological examination was done before and 6-months after treatment, specimens were stained by haematoxylin and eosin, Mallory trichrome and Verhoeff-Van Gieson. Results: In both groups; 70% showed excellent and very good improvement and patients’ satisfaction was 60% for both groups. Histopathological examination revealed increase in epidermal thickness, formation of new collagen and elastic fibers without significant difference between both groups. Conclusion: Nanofat transfer is easy, cost-effective, and safe for treating acne scars, compared to enhanced nanofat with ADSCs transfer which is costly and time consuming