The Effect of Inhalation of Fumes from Esbiothrin Based Mosquito Coil on Some Renal Function Markers and Hematological Parameters in Male Wistar Rats

Abstract

Esbiothrin is a synthetic pyrethroid with quick activity used in public health against mosquitoes, houseflies, ectoparasites and cockroaches as well as agricultural applications. These coils and the inhalation of their fumes have been reported and proved to cause grave consequences to the respiratory tract majorly. Hence, this current study was aimed at assessing the renal and hematological effect of inhalation of fumes from esbiothrin based mosquito coil using experimental animal models. Ten (10) male wistar albino rats were divided into two (2) groups (A and F) of five rats each. Rats in group A were named control and were therefore not exposed to esbiothrin based mosquito coil fumes while group F animals were named test group and were exposed to esbiothrin based mosquito coil fumes for about 6 hours per day, five (5) days per week for four (4) weeks. At the end of the experimental period, blood was collected from each rat for the hematological analysis of Red Blood Cell (RBC), White Blood Cell (WBC), Packed Cell Volume and platelets Count using automated hematology analyzer and also for the analysis of some renal function markers (urea and creatinine). Result revealed that test group had a significant decrease (p>0.05) in urea level while there was no significant difference in the creatinine levels. Results further showed a significant decrease (p>0.05) in the WBC count, RBC count, PCV and PLT count.  Results from this study indicates that esbiothrin based mosquito coil fumes, though considered the least toxic insecticide, are very capable of causing harm.